Amgad Droby, Kenneth S. L. Yuen, Muthuraman Muthuraman, Sarah-Christina Reitz, Vinzenz Fleischer, Johannes Klein, René-Maxime Gracien, Ulf Ziemann, Ralf Deichmann, Frauke Zipp, Sergiu Groppa
- Diffuse inflammation in multiple sclerosis (MS) extends beyond focal lesion sites, affecting interconnected regions; however, little is known about the impact of an individual lesion affecting major white matter (WM) pathways on brain functional connectivity (FC). Here, we longitudinally assessed the effects of acute and chronic lesions on FC in relapsing-remitting MS (RRMS) patients using resting-state fMRI. 45 MRI data sets from 9 RRMS patients were recorded using 3T MR scanner over 5 time points at 8 week intervals. Patients were divided into two groups based on the presence (n = 5; MS+) and absence (n = 4; MS-) of a lesion at a predilection site for MS. While FC levels were found not to fluctuate significantly in the overall patient group, the MS+ patient group showed increased FC in the contralateral cuneus and precuneus and in the ipsilateral precuneus (p < 0.01, corrected). This can be interpreted as the recruitment of intact cortical regions to compensate for tissue damage.Diffuse inflammation in multiple sclerosis (MS) extends beyond focal lesion sites, affecting interconnected regions; however, little is known about the impact of an individual lesion affecting major white matter (WM) pathways on brain functional connectivity (FC). Here, we longitudinally assessed the effects of acute and chronic lesions on FC in relapsing-remitting MS (RRMS) patients using resting-state fMRI. 45 MRI data sets from 9 RRMS patients were recorded using 3T MR scanner over 5 time points at 8 week intervals. Patients were divided into two groups based on the presence (n = 5; MS+) and absence (n = 4; MS-) of a lesion at a predilection site for MS. While FC levels were found not to fluctuate significantly in the overall patient group, the MS+ patient group showed increased FC in the contralateral cuneus and precuneus and in the ipsilateral precuneus (p < 0.01, corrected). This can be interpreted as the recruitment of intact cortical regions to compensate for tissue damage. During the study, one patient developed an acute WM lesion in the left posterior periventricular space. A marked increase in FC in the right pre-, post-central gyrus, right superior frontal gyrus, the left cuneus, the vermis and the posterior and anterior lobes of the cerebellum was noted following the clinical relapse, which gradually decreased in subsequent follow-ups, suggesting short-term functional reorganization during the acute phase. This strongly suggests that the lesion-related network changes observed in patients with chronic lesions occur as a result of reorganization processes following the initial appearance of an acute lesion.…
MetadatenAuthor: | Amgad Droby, Kenneth S. L. Yuen, Muthuraman MuthuramanORCiDGND, Sarah-Christina Reitz, Vinzenz Fleischer, Johannes Klein, René-Maxime Gracien, Ulf Ziemann, Ralf Deichmann, Frauke Zipp, Sergiu Groppa |
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URN: | urn:nbn:de:bvb:384-opus4-1102346 |
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Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/110234 |
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ISSN: | 1931-7557OPAC |
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ISSN: | 1931-7565OPAC |
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Parent Title (English): | Brain Imaging and Behavior |
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Publisher: | Springer Science and Business Media LLC |
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Place of publication: | Berlin |
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Type: | Article |
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Language: | English |
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Year of first Publication: | 2016 |
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Publishing Institution: | Universität Augsburg |
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Release Date: | 2023/12/15 |
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Tag: | Behavioral Neuroscience; Psychiatry and Mental health; Cellular and Molecular Neuroscience; Neurology (clinical); Cognitive Neuroscience; Neurology; Radiology, Nuclear Medicine and imaging |
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Volume: | 10 |
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Issue: | 4 |
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First Page: | 1117 |
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Last Page: | 1126 |
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DOI: | https://doi.org/10.1007/s11682-015-9476-3 |
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Institutes: | Fakultät für Angewandte Informatik |
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| Fakultät für Angewandte Informatik / Institut für Informatik |
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| Fakultät für Angewandte Informatik / Institut für Informatik / Professur für Informatik in der Medizintechnik |
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Dewey Decimal Classification: | 0 Informatik, Informationswissenschaft, allgemeine Werke / 00 Informatik, Wissen, Systeme / 004 Datenverarbeitung; Informatik |
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Licence (German): | Deutsches Urheberrecht |
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