Daniel Schwarzkopf, Norman Rose, Carolin Fleischmann-Struzek, Beate Boden, Heike Dorow, Andreas Edel, Marcus Friedrich, Falk A. Gonnert, Jürgen Götz, Matthias Gründling, Markus Heim, Kirill Holbeck, Ulrich Jaschinski, Christian Koch, Christian Künzer, Khanh Le Ngoc, Simone Lindau, Ngoc Bich Mehlmann, Jan Meschede, Patrick Meybohm, Dominique Ouart, Christian Putensen, Michael Sander, Jens-Christian Schewe, Peter Schlattmann, Götz Schmidt, Gerhard Schneider, Claudia Spies, Ferdinand Steinsberger, Kai Zacharowski, Sebastian Zinn, Konrad Reinhart
- Purpose
Timely and accurate data on the epidemiology of sepsis are essential to inform policy decisions and research priorities. We aimed to investigate the validity of inpatient administrative health data (IAHD) for surveillance and quality assurance of sepsis care.
Methods
We conducted a retrospective validation study in a disproportional stratified random sample of 10,334 inpatient cases of age ≥ 15 years treated in 2015–2017 in ten German hospitals. The accuracy of coding of sepsis and risk factors for mortality in IAHD was assessed compared to reference standard diagnoses obtained by a chart review. Hospital-level risk-adjusted mortality of sepsis as calculated from IAHD information was compared to mortality calculated from chart review information.
Results
ICD-coding of sepsis in IAHD showed high positive predictive value (76.9–85.7% depending on sepsis definition), but low sensitivity (26.8–38%), which led to an underestimation of sepsis incidence (1.4% vs. 3.3% forPurpose
Timely and accurate data on the epidemiology of sepsis are essential to inform policy decisions and research priorities. We aimed to investigate the validity of inpatient administrative health data (IAHD) for surveillance and quality assurance of sepsis care.
Methods
We conducted a retrospective validation study in a disproportional stratified random sample of 10,334 inpatient cases of age ≥ 15 years treated in 2015–2017 in ten German hospitals. The accuracy of coding of sepsis and risk factors for mortality in IAHD was assessed compared to reference standard diagnoses obtained by a chart review. Hospital-level risk-adjusted mortality of sepsis as calculated from IAHD information was compared to mortality calculated from chart review information.
Results
ICD-coding of sepsis in IAHD showed high positive predictive value (76.9–85.7% depending on sepsis definition), but low sensitivity (26.8–38%), which led to an underestimation of sepsis incidence (1.4% vs. 3.3% for severe sepsis-1). Not naming sepsis in the chart was strongly associated with under-coding of sepsis. The frequency of correctly naming sepsis and ICD-coding of sepsis varied strongly between hospitals (range of sensitivity of naming: 29–71.7%, of ICD-diagnosis: 10.7–58.5%). Risk-adjusted mortality of sepsis per hospital calculated from coding in IAHD showed no substantial correlation to reference standard risk-adjusted mortality (r = 0.09).
Conclusion
Due to the under-coding of sepsis in IAHD, previous epidemiological studies underestimated the burden of sepsis in Germany. There is a large variability between hospitals in accuracy of diagnosing and coding of sepsis. Therefore, IAHD alone is not suited to assess quality of sepsis care.…
MetadatenAuthor: | Daniel Schwarzkopf, Norman Rose, Carolin Fleischmann-Struzek, Beate Boden, Heike Dorow, Andreas Edel, Marcus Friedrich, Falk A. Gonnert, Jürgen Götz, Matthias Gründling, Markus Heim, Kirill Holbeck, Ulrich Jaschinski, Christian Koch, Christian Künzer, Khanh Le Ngoc, Simone Lindau, Ngoc Bich Mehlmann, Jan Meschede, Patrick Meybohm, Dominique Ouart, Christian Putensen, Michael Sander, Jens-Christian Schewe, Peter Schlattmann, Götz Schmidt, Gerhard Schneider, Claudia Spies, Ferdinand Steinsberger, Kai Zacharowski, Sebastian Zinn, Konrad Reinhart |
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URN: | urn:nbn:de:bvb:384-opus4-1098900 |
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Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/109890 |
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ISSN: | 0300-8126OPAC |
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ISSN: | 1439-0973OPAC |
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Parent Title (English): | Infection |
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Publisher: | Springer Science and Business Media LLC |
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Place of publication: | Berlin |
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Type: | Article |
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Language: | English |
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Year of first Publication: | 2024 |
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Publishing Institution: | Universität Augsburg |
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Release Date: | 2024/01/08 |
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Tag: | Infectious Diseases; Microbiology (medical); General Medicine |
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Volume: | 52 |
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First Page: | 413 |
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Last Page: | 427 |
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DOI: | https://doi.org/10.1007/s15010-023-02091-y |
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Institutes: | Medizinische Fakultät |
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| Medizinische Fakultät / Universitätsklinikum |
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| Medizinische Fakultät / Lehrstuhl für Anästhesiologie und Operative Intensivmedizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Licence (German): | CC-BY 4.0: Creative Commons: Namensnennung (mit Print on Demand) |
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