Thomas Traunwieser, Elena Loos, Holger Ottensmeier, Katharina Gastberger, Karolina Nemes, Martin Mynarek, Brigitte Bison, Daniela Kandels, Petra Neumayer, Anne Neumann‐Holbeck, Peggy Lüttich, Katja Baust, Kristin Faulstich‐Ritter, Rainer John, Andrea Kreisch, Judyta Landmann, Eva Manteufel, Alexandra Nest, Jenny Prüfe, Lisa Schubert, Walther Stamm, Beate Timmermann, Joachim Gerss, Stefan Rutkowski, Paul‐Gerhardt Schlegel, Matthias Eyrich, Astrid K. Gnekow, Michael C. Frühwald
- Background
The contribution of tumor type, multimodal treatment, and other patient-related factors upon long-term cognitive sequelae in infant brain tumor survivors remains undefined. We add our retrospective analysis of neuropsychological and quality of survival (QoS) outcome data of survivors of atypical teratoid/rhabdoid tumors (ATRT) and extracranial malignant rhabdoid tumors of the soft tissues (eMRT) and kidneys (RTK) treated within the same framework. Neuropsychological data from children with ATRT were compared to data from children with non-irradiated low-grade glioma (LGG).
Patients and methods
Following surgery, patients (0–36 months at diagnosis) had received radio-chemotherapy (up to 54 Gy; ATRT: n = 13; eMRT/RTK: n = 7), chemotherapy only (LGG: n = 4; eMRT/RTK: n = 1) or had been observed (LGG: n = 11). Neuropsychological evaluation employing comparable tests was performed at median 6.8 years (ATRT), 6.6 years (eMRT/RTK), and 5.2 years (LGG) postBackground
The contribution of tumor type, multimodal treatment, and other patient-related factors upon long-term cognitive sequelae in infant brain tumor survivors remains undefined. We add our retrospective analysis of neuropsychological and quality of survival (QoS) outcome data of survivors of atypical teratoid/rhabdoid tumors (ATRT) and extracranial malignant rhabdoid tumors of the soft tissues (eMRT) and kidneys (RTK) treated within the same framework. Neuropsychological data from children with ATRT were compared to data from children with non-irradiated low-grade glioma (LGG).
Patients and methods
Following surgery, patients (0–36 months at diagnosis) had received radio-chemotherapy (up to 54 Gy; ATRT: n = 13; eMRT/RTK: n = 7), chemotherapy only (LGG: n = 4; eMRT/RTK: n = 1) or had been observed (LGG: n = 11). Neuropsychological evaluation employing comparable tests was performed at median 6.8 years (ATRT), 6.6 years (eMRT/RTK), and 5.2 years (LGG) post diagnosis.
Results
We detected sequelae in various domains for all tumor types. Group comparison showed impairments, specifically in fluid intelligence (p = .041; d = 1.11) and visual processing (p = .001; d = 2.09) in ATRT patients when compared to LGG patients. Results for psychomotor speed and attention abilities were significantly below the norm for both groups (p < .001–.019; d = 0.79–1.90). Diagnosis predicted impairments of cognitive outcome, while sex- and age-related variables did not. QoS outcome for all rhabdoid patients displayed impairments mainly in social (p = .008; d = 0.74) and school functioning (p = .048; d = 0.67), as well as lower overall scores in psychosocial functioning (p = .023; d = 0.78) and quality of life (p = .006; d = 0.79) compared to healthy controls.
Conclusion
Survivors of infant ATRT experience various late effects in cognition and QoS following multimodal treatment, while infant LGG patients without radiotherapy demonstrated comparable impairments in psychomotor and attention abilities. Early onset and multimodal treatment of rhabdoid tumors require close monitoring of neuropsychological and QoS sequelae.…
MetadatenAuthor: | Thomas Traunwieser, Elena Loos, Holger Ottensmeier, Katharina Gastberger, Karolina Nemes, Martin Mynarek, Brigitte Bison, Daniela Kandels, Petra Neumayer, Anne Neumann‐Holbeck, Peggy Lüttich, Katja Baust, Kristin Faulstich‐Ritter, Rainer John, Andrea Kreisch, Judyta Landmann, Eva Manteufel, Alexandra Nest, Jenny Prüfe, Lisa Schubert, Walther Stamm, Beate Timmermann, Joachim Gerss, Stefan Rutkowski, Paul‐Gerhardt Schlegel, Matthias Eyrich, Astrid K. Gnekow, Michael C. FrühwaldGND |
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Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/111702 |
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ISSN: | 1545-5009OPAC |
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ISSN: | 1545-5017OPAC |
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Parent Title (English): | Pediatric Blood & Cancer |
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Publisher: | Wiley |
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Place of publication: | Weinheim |
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Type: | Article |
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Language: | English |
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Year of first Publication: | 2024 |
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Publishing Institution: | Universität Augsburg |
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Release Date: | 2024/02/29 |
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Tag: | Oncology; Hematology; Pediatrics, Perinatology and Child Health |
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First Page: | e30910 |
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DOI: | https://doi.org/10.1002/pbc.30910 |
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Institutes: | Medizinische Fakultät |
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| Medizinische Fakultät / Universitätsklinikum |
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| Medizinische Fakultät / Lehrstuhl für Kinder- und Jugendmedizin |
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| Medizinische Fakultät / Lehrstuhl für Diagnostische und Interventionelle Neuroradiologie |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Latest Publications (not yet published in print): | Aktuelle Publikationen (noch nicht gedruckt erschienen) |
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Licence (German): | CC-BY-NC 4.0: Creative Commons: Namensnennung - Nicht kommerziell (mit Print on Demand) |
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