TY  - JOUR
A1  - Tan, Tzer Han
A1  - Malik-Garbi, Maya
A1  - Abu-Shah, Enas
A1  - Li, Junang
A1  - Sharma, Abhinav
A1  - MacKintosh, Fred C.
A1  - Keren, Kinneret
A1  - Schmidt, Christoph F.
A1  - Fakhri, Nikta
T1  - Self-organized stress patterns drive state transitions in actin cortices
T2  - Science Advances
N2  - Biological functions rely on ordered structures and intricately controlled collective dynamics. This order in living systems is typically established and sustained by continuous dissipation of energy. The emergence of collective patterns of motion is unique to nonequilibrium systems and is a manifestation of dynamic steady states. Mechanical resilience of animal cells is largely controlled by the actomyosin cortex. The cortex provides stability but is, at the same time, highly adaptable due to rapid turnover of its components. Dynamic functions involve regulated transitions between different steady states of the cortex. We find that model actomyosin cortices, constructed to maintain turnover, self-organize into distinct nonequilibrium steady states when we vary cross-link density. The feedback between actin network structure and organization of stress-generating myosin motors defines the symmetries of the dynamic steady states. A marginally cross-linked state displays divergence-free long-range flow patterns. Higher cross-link density causes structural symmetry breaking, resulting in a stationary converging flow pattern. We track the flow patterns in the model actomyosin cortices using fluorescent single-walled carbon nanotubes as novel probes. The self-organization of stress patterns we have observed in a model system can have direct implications for biological functions.
Y1  - 2018
UR  - https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/103826
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1038264
SN  - 2375-2548
VL  - 4
IS  - 6
SP  - eaar2847
PB  - American Association for the Advancement of Science (AAAS)
CY  - Washington, DC
ER  -