TY  - JOUR
A1  - Loch, Florian N.
A1  - Kamphues, Carsten
A1  - Beyer, Katharina
A1  - Schineis, Christian
A1  - Rayya, Wael
A1  - Lauscher, Johannes C.
A1  - Horst, David
A1  - Dragomir, Mihnea P.
A1  - Schallenberg, Simon
T1  - The immune checkpoint landscape in tumor cells of pancreatic ductal adenocarcinoma
T2  - International Journal of Molecular Sciences
N2  - Immune checkpoint therapy (ICT) has shown promising potential in the treatment of multiple solid tumors. However, the role of ICT in pancreatic ductal adenocarcinoma (PDAC) remains limited. Patterns of immune checkpoints (ICs) in PDAC represent the basis for establishing a potent ICT. The aim of this study is to create a profile of IC expression and its prognostic relevance in cancer cells of PDAC. Therefore, tumor cells from peripheral and central tissue microarray (TMA) spots from histologically confirmed PDAC of 68 patients after tumor resection were investigated in terms of expressions of TIM3, IDO, B7H4, LAG3, VISTA, and PD-L1 using immunohistochemistry. The presence of the respective ICs was compared to overall survival (OS). The presence of VISTA and PD-L1 significantly correlates with shorter OS (median OS: 22 months vs. 7 months and 22 months vs. 11 months, respectively, p < 0.05). For the presence of TIM3, IDO, B7H4, and LAG3, no difference in OS was observed (p > 0.05). The analysis of OS of combined subgroups for VISTA and PD-L1 (VISTA and PD-L1 neg., VISTA pos. and PD-L1 neg., VISTA neg. and PD-L1 pos., and VISTA and PD-L1 pos.) yielded overall statistical significance difference (p = 0.02). These results suggest that the presence of VISTA and PD-L1 is of prognostic relevance and potentially qualifies them as targets for ICT.
Y1  - 2023
UR  - https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/123748
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1237483
SN  - 1422-0067
VL  - 24
IS  - 3
SP  - 2160
PB  - MDPI AG
CY  - Basel
ER  -