TY  - JOUR
A1  - Degro, Claudius E.
A1  - Strozynski, Richard
A1  - Loch, Florian N.
A1  - Schineis, Christian
A1  - Speichinger, Fiona
A1  - Lee, Lucas D.
A1  - Margonis, Georgios A.
A1  - Lauscher, Johannes C.
A1  - Beyer, Katharina
A1  - Kreis, Martin E.
A1  - Kamphues, Carsten
T1  - Survival rates and prognostic factors in right- and left-sided colon cancer stage I–IV: an unselected retrospective single-center trial
T2  - International Journal of Colorectal Disease
N2  - Purpose Colorectal cancer revealed over the last decades a remarkable shift with an increasing proportion of a right- compared to a left-sided tumor location. In the current study, we aimed to disclose clinicopathological differences between right- and left-sided colon cancer (rCC and lCC) with respect to mortality and outcome predictors. Methods In total, 417 patients with colon cancer stage I–IV were analyzed in the present retrospective single-center study. Survival rates were assessed using the Kaplan–Meier method and uni/multivariate analyses were performed with a Cox proportional hazards regression model. Results Our study showed no significant difference of the overall survival between rCC and lCC stage I–IV ( p = 0.354). Multivariate analysis revealed in the rCC cohort the worst outcome for ASA (American Society of Anesthesiologists) score IV patients (hazard ratio [HR]: 16.0; CI 95%: 2.1–123.5), CEA (carcinoembryonic antigen) blood level > 100 µg/l (HR: 3.3; CI 95%: 1.2–9.0), increased lymph node ratio of 0.6–1.0 (HR: 5.3; CI 95%: 1.7–16.1), and grade 4 tumors (G4) (HR: 120.6; CI 95%: 6.7–2179.6) whereas in the lCC population, ASA score IV (HR: 8.9; CI 95%: 0.9–91.9), CEA blood level 20.1–100 µg/l (HR: 5.4; CI 95%: 2.4–12.4), conversion to laparotomy (HR: 14.1; CI 95%: 4.0–49.0), and severe surgical complications (Clavien-Dindo III–IV) (HR: 2.9; CI 95%: 1.5–5.5) were identified as predictors of a diminished overall survival. Conclusion Laterality disclosed no significant effect on the overall prognosis of colon cancer patients. However, group differences and distinct survival predictors could be identified in rCC and lCC patients.
Y1  - 2021
UR  - https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/123830
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1238308
SN  - 0179-1958
SN  - 1432-1262
VL  - 36
IS  - 12
SP  - 2683
EP  - 2696
PB  - Springer Science and Business Media LLC
ER  -