TY  - JOUR
T1  - Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic
T2  - British Journal of Surgery
N2  - Background: This study aimed to determine the impact of pulmonary complications on death after surgery both before and during
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

Methods: This was a patient-level, comparative analysis of two, international prospective cohort studies: one before the pandemic
(January–October 2019) and the second during the SARS-CoV-2 pandemic (local emergence of COVID-19 up to 19 April 2020). Both in-
cluded patients undergoing elective resection of an intra-abdominal cancer with curative intent across five surgical oncology
disciplines. Patient selection and rates of 30-day postoperative pulmonary complications were compared. The primary outcome was
30-day postoperative mortality. Mediation analysis using a natural-effects model was used to estimate the proportion of deaths
during the pandemic attributable to SARS-CoV-2 infection.

Results: This study included 7402 patients from 50 countries; 3031 (40.9 per cent) underwent surgery before and 4371 (59.1 per cent)
during the pandemic. Overall, 4.3 per cent (187 of 4371) developed postoperative SARS-CoV-2 in the pandemic cohort. The pulmonary
complication rate was similar (7.1 per cent (216 of 3031) versus 6.3 per cent (274 of 4371); P¼0.158) but the mortality rate was signifi-
cantly higher (0.7 per cent (20 of 3031) versus 2.0 per cent (87 of 4371); P<0.001) among patients who had surgery during the pandemic.
The adjusted odds of death were higher during than before the pandemic (odds ratio (OR) 2.72, 95 per cent c.i. 1.58 to 4.67; P<0.001).
In mediation analysis, 54.8 per cent of excess postoperative deaths during the pandemic were estimated to be attributable to
SARS-CoV-2 (OR 1.73, 1.40 to 2.13; P<0.001).

Conclusion: Although providers may have selected patients with a lower risk profile for surgery during the pandemic, this did not
mitigate the likelihood of death through SARS-CoV-2 infection. Care providers must act urgently to protect surgical patients from
SARS-CoV-2 infection.
Y1  - 2021
UR  - https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/123832
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1238327
SN  - 0007-1323
SN  - 1365-2168
N1  - Published on behalf of the STARSurg Collaborative and COVIDSurg Collaborative. Please see publisher's website for a complete list of authors.
VL  - 108
IS  - 12
SP  - 1448
EP  - 1464
PB  - Oxford University Press (OUP)
ER  -