TY  - JOUR
A1  - Kessler, Wolfram
A1  - Diedrich, Stephan
A1  - Menges, Pia
A1  - Ebker, Tobias
A1  - Nielson, Michael
A1  - Partecke, Lars Ivo
A1  - Traeger, Tobias
A1  - Cziupka, Katharina
A1  - van der Linde, Julia
A1  - Puls, Ralf
A1  - Busemann, Alexandra
A1  - Heidecke, Claus-Dieter
A1  - Maier, Stefan
T1  - The role of the vagus nerve: modulation of the inflammatory reaction in murine polymicrobial sepsis
T2  - Mediators of Inflammation
N2  - The particular importance of the vagus nerve for the pathophysiology of peritonitis becomes more and more apparent. In this work we provide evidence for the vagal modulation of inflammation in the murine model of colon ascendens stent peritonitis (CASP). Vagotomy significantly increases mortality in polymicrobial sepsis. This effect is not accounted for by the dilatation of gastric volume following vagotomy. As the stimulation of cholinergic receptors by nicotine has no therapeutic effect, the lack of nicotine is also not the reason for the reduced survival rate. In fact, increased septic mortality is a consequence of the absent modulating influence of the vagus nerve on the immune system: we detected significantly elevated serum corticosterone levels in vagotomised mice 24 h following CASP and a decreased ex vivo TNF-alpha secretion of Kupffer cells upon stimulation with LPS. In conclusion, the vagus nerve has a modulating influence in polymicrobial sepsis by attenuating the immune dysregulation.
Y1  - 2012
UR  - https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/124147
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1241477
SN  - 0962-9351
SN  - 1466-1861
VL  - 2012
SP  - 467620
PB  - Hindawi
ER  -