TY  - JOUR
A1  - Vollmuth, Yannik
A1  - Jungbäck, Nicola
A1  - Mögele, Tatiana
A1  - Schmidt-Graf, Friederike
A1  - Wunderlich, Silke
A1  - Schimmel, Mareike
A1  - Rothe, Camilla
A1  - Stark, Leonhard
A1  - Schlegel, Jürgen
A1  - Rieder, Georg
A1  - Richter, Thomas
A1  - Schaller, Tina
A1  - Tappe, Dennis
A1  - Märkl, Bruno
A1  - Matiasek, Kaspar
A1  - Liesche-Starnecker, Friederike
T1  - Comparative study of virus and lymphocyte distribution with clinical data suggests early high dose immunosuppression as potential key factor for the therapy of patients with BoDV-1 infection
T2  - Emerging Microbes & Infections
N2  - Borna disease virus 1 (BoDV-1) was just recently shown to cause predominantly fatal encephalitis in humans. Despite its rarity, bornavirus encephalitis (BVE) can be considered a model disease for encephalitic infections caused by neurotropic viruses and understanding its pathomechanism is of utmost relevance. Aim of this study was to compare the extent and distribution pattern of cerebral inflammation with the clinical course of disease, and individual therapeutic procedures. For this, autoptic brain material from seven patients with fatal BVE was included in this study. Tissue was stained immunohistochemically for pan-lymphocytic marker CD45, the nucleoprotein of BoDV-1, as well as glial marker GFAP and microglial marker Iba1. Sections were digitalized and counted for CD45-positive and BoDV-1-positive cells. For GFAP and Iba1, a semiquantitative score was determined. Furthermore, detailed information about the individual clinical course and therapy were retrieved and summarized in a standardized way. Analysis of the distribution of lymphocytes shows interindividual patterns. In contrast, when looking at the BoDV-1-positive glial cells and neurons, a massive viral involvement in the brain stem was noticeable. Three of the seven patients received early high-dose steroids, which led to a significantly lower lymphocytic infiltration of the central nervous tissue and a longer survival compared to the patients who were treated with steroids later in the course of disease. This study highlights the potential importance of early high-dose immunosuppressive therapy in BVE. Our findings hint at a promising treatment option which should be corroborated in future observational or prospective therapy studies.
Y1  - 2024
UR  - https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/113414
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1134145
SN  - 2222-1751
VL  - 13
IS  - 1
SP  - 2350168
PB  - Informa UK Limited
ER  -