[18F]FET-PET in children and adolescents with central nervous system tumors: does it support difficult clinical decision-making?

  • Purpose Positron emission tomography (PET) with O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) is a well-established tool for non-invasive assessment of adult central nervous system (CNS) tumors. However, data on its diagnostic utility and impact on clinical management in children and adolescents are limited. Methods Twenty-one children and young adults (13 males; mean age, 8.6 ± 5.2 years; range, 1–19 at initial diagnosis) with either newly diagnosed (n = 5) or pretreated (n = 16) CNS tumors were retrospectively analyzed. All patients had previously undergone neuro-oncological work-up including cranial magnetic resonance imaging. In all cases, [18F]FET-PET was indicated in a multidisciplinary team conference. The impact of PET imaging on clinical decision-making was assessed. Histopathology (n = 12) and/or clinical and imaging follow-up (n = 9) served as the standard of reference. Results The addition of [18F]FET-PET to the available information had an impact on furtherPurpose Positron emission tomography (PET) with O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) is a well-established tool for non-invasive assessment of adult central nervous system (CNS) tumors. However, data on its diagnostic utility and impact on clinical management in children and adolescents are limited. Methods Twenty-one children and young adults (13 males; mean age, 8.6 ± 5.2 years; range, 1–19 at initial diagnosis) with either newly diagnosed (n = 5) or pretreated (n = 16) CNS tumors were retrospectively analyzed. All patients had previously undergone neuro-oncological work-up including cranial magnetic resonance imaging. In all cases, [18F]FET-PET was indicated in a multidisciplinary team conference. The impact of PET imaging on clinical decision-making was assessed. Histopathology (n = 12) and/or clinical and imaging follow-up (n = 9) served as the standard of reference. Results The addition of [18F]FET-PET to the available information had an impact on further patient management in 14 out of 21 subjects, with avoidance of invasive surgery or biopsy in four patients, biopsy guidance in four patients, change of further treatment in another five patients, and confirmation of diagnosis in one patient. Conclusion [18F]FET-PET may provide important additional information for treatment guidance in pediatric and adolescent patients with CNS tumors.show moreshow less

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Author:Olivia Kertels, Jürgen Krauß, Camelia Maria Monoranu, Samuel Samnick, Alexander DierksGND, Malte KircherORCiDGND, Milena I. Mihovilovic, Mirko Pham, Andreas K. Buck, Matthias Eyrich, Paul-Gerhardt Schlegel, Michael C. FrühwaldGND, Brigitte Bison, Constantin LapaORCiDGND
URN:urn:nbn:de:bvb:384-opus4-1023188
Frontdoor URLhttps://opus.bibliothek.uni-augsburg.de/opus4/102318
ISSN:1619-7070OPAC
ISSN:1619-7089OPAC
Parent Title (English):European Journal of Nuclear Medicine and Molecular Imaging
Publisher:Springer
Place of publication:Berlin
Type:Article
Language:English
Year of first Publication:2023
Publishing Institution:Universität Augsburg
Release Date:2023/02/27
Tag:Radiology, Nuclear Medicine and imaging; General Medicine
Volume:50
First Page:1699
Last Page:1708
DOI:https://doi.org/10.1007/s00259-023-06114-6
Institutes:Medizinische Fakultät
Medizinische Fakultät / Universitätsklinikum
Medizinische Fakultät / Lehrstuhl für Kinder- und Jugendmedizin
Medizinische Fakultät / Lehrstuhl für Nuklearmedizin
Medizinische Fakultät / Lehrstuhl für Diagnostische und Interventionelle Neuroradiologie
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):CC-BY 4.0: Creative Commons: Namensnennung (mit Print on Demand)