Hedgehog signaling pathway in ovarian cancer
- Despite advances in surgical and chemotherapeutic treatment options, less than 50% of patients with advanced-stage ovarian cancer survive five years after initial diagnosis. In this regard, novel treatment approaches are warranted utilizing molecularly targeted therapies directed against particular components of specific signaling pathways which are required for tumor development and progression. One molecular pathway of interest is the hedgehog (Hh) signaling pathway. Activation of the Hh pathway has been observed in several cancer types, including ovarian cancer. This review highlights the crucial role of Hh signaling in the development and progression of ovarian cancer and might lead to a better understanding of the Hh signaling in ovarian tumorigenesis, thus encouraging the investigation of novel targeted therapies.
Download full text files
Statistics
Print On Demand
Additional Services
| Author: | Joanna Szkandera, Tobias Kiesslich, Johannes Haybaeck, Armin Gerger, Martin PichlerGND |
|---|---|
| URN: | urn:nbn:de:bvb:384-opus4-1052603 |
| Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/105260 |
| ISSN: | 1422-0067OPAC |
| Parent Title (English): | International Journal of Molecular Sciences |
| Publisher: | MDPI AG |
| Place of publication: | Basel |
| Type: | Article |
| Language: | English |
| Year of first Publication: | 2013 |
| Publishing Institution: | Universität Augsburg |
| Release Date: | 2023/06/28 |
| Tag: | Inorganic Chemistry; Organic Chemistry; Physical and Theoretical Chemistry; Computer Science Applications; Spectroscopy; Molecular Biology; General Medicine; Catalysis |
| Volume: | 14 |
| Issue: | 1 |
| First Page: | 1179 |
| Last Page: | 1196 |
| DOI: | https://doi.org/10.3390/ijms14011179 |
| Institutes: | Medizinische Fakultät |
| Medizinische Fakultät / Universitätsklinikum | |
| Medizinische Fakultät / Professur für Translationale Krebsforschung | |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Licence (German): |  CC-BY 4.0: Creative Commons: Namensnennung (mit Print on Demand) |
