Association between body fat distribution and B-lymphocyte subsets in peripheral blood

  • Background Obesity is associated with chronic low-grade inflammation, which is underpinned by the presence of elevated levels of circulating proinflammatory cytokines in obese individuals. Due to the close relationship between adipose tissue and the immune system, it can be speculated that the accumulation of fat may influence the frequency and phenotype of lymphocyte populations. The aim of our study was to investigate whether body fat distribution is associated with B lymphocyte composition in peripheral blood. We examined the association between visceral (VAT) and total body fat (TBF) and the frequencies of B-cell subsets in 238 subjects over a period of up to one year using random intercept models. B lymphocyte subsets were determined by fluorescence-based flow cytometry. Results Inverse associations were found between body fat measurements and plasma blasts, memory B cells, and IgM−IgD− cells. VAT, but not TBF, was positively associated with naive CD19 cells. In our analyses,Background Obesity is associated with chronic low-grade inflammation, which is underpinned by the presence of elevated levels of circulating proinflammatory cytokines in obese individuals. Due to the close relationship between adipose tissue and the immune system, it can be speculated that the accumulation of fat may influence the frequency and phenotype of lymphocyte populations. The aim of our study was to investigate whether body fat distribution is associated with B lymphocyte composition in peripheral blood. We examined the association between visceral (VAT) and total body fat (TBF) and the frequencies of B-cell subsets in 238 subjects over a period of up to one year using random intercept models. B lymphocyte subsets were determined by fluorescence-based flow cytometry. Results Inverse associations were found between body fat measurements and plasma blasts, memory B cells, and IgM−IgD− cells. VAT, but not TBF, was positively associated with naive CD19 cells. In our analyses, both VAT and TBF showed positive associations with IgD only B cells. Conclusions In conclusion, body fat accumulation seems to be associated with a lower proportion of antibodysecreting plasma blasts and memory cells and an increasing amount of partially anergic, naive CD19 cells.show moreshow less

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Metadaten
Author:Pia Prechtl, Timo Schmitz, Nicole Pochert, Claudia Traidl-HoffmannORCiDGND, Jakob LinseisenGND, Christa MeisingerGND, Dennis FreuerORCiDGND
URN:urn:nbn:de:bvb:384-opus4-1076817
Frontdoor URLhttps://opus.bibliothek.uni-augsburg.de/opus4/107681
ISSN:1742-4933OPAC
Parent Title (English):Immunity & Ageing
Publisher:Springer
Place of publication:Berlin
Type:Article
Language:English
Year of first Publication:2023
Publishing Institution:Universität Augsburg
Release Date:2023/09/18
Tag:Aging; Immunology
Volume:20
Issue:1
First Page:47
DOI:https://doi.org/10.1186/s12979-023-00372-6
Institutes:Medizinische Fakultät
Medizinische Fakultät / Universitätsklinikum
Medizinische Fakultät / Lehrstuhl für Umweltmedizin
Medizinische Fakultät / Lehrstuhl für Epidemiologie
Nachhaltigkeitsziele
Nachhaltigkeitsziele / Ziel 3 - Gesundheit und Wohlergehen
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):CC-BY 4.0: Creative Commons: Namensnennung (mit Print on Demand)