A structural perspective of CTD function
- The C-terminal domain (CTD) of RNA polymerase II (Pol II) integrates nuclear events by binding proteins involved in mRNA biogenesis. CTD-binding proteins recognize a specific CTD phosphorylation pattern, which changes during the transcription cycle, due to the action of CTD-modifying enzymes. Structural and functional studies of CTD-binding and -modifying proteins now reveal some of the mechanisms underlying CTD function. Proteins recognize CTD phosphorylation patterns either directly, by contacting phosphorylated residues, or indirectly, without contact to the phosphate. The catalytic mechanisms of CTD kinases and phosphatases are known, but the basis for CTD specificity of these enzymes remains to be understood.
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| Author: | Anton Meinhart, Tomislav Kamenski, Sabine HoeppnerGND, Sonja Baumli, Patrick Cramer |
|---|---|
| URN: | urn:nbn:de:bvb:384-opus4-1099322 |
| Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/109932 |
| ISSN: | 0890-9369OPAC |
| ISSN: | 1549-5477OPAC |
| Parent Title (English): | Genes & Development |
| Publisher: | Cold Spring Harbor Laboratory |
| Place of publication: | Woodbury, NY |
| Type: | Article |
| Language: | English |
| Year of first Publication: | 2005 |
| Publishing Institution: | Universität Augsburg |
| Release Date: | 2023/12/11 |
| Tag: | Developmental Biology; Genetics |
| Volume: | 19 |
| Issue: | 12 |
| First Page: | 1401 |
| Last Page: | 1415 |
| DOI: | https://doi.org/10.1101/gad.1318105 |
| Institutes: | Medizinische Fakultät |
| Medizinische Fakultät / Lehrstuhl für Biochemie und Molekularbiologie | |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Licence (German): |  CC-BY-NC 4.0: Creative Commons: Namensnennung - Nicht kommerziell (mit Print on Demand) |
