Open Access

Muthuraman Muthuraman, H. Hellriegel, C. J. Hartmann, Nienke Hoogenboom, Holger Krause, Kidist Gebremariam Mideksa, Martin Südmeyer, Alfons Schnitzler, Günther Deuschl

• Background / Purpose The first aim of this study was to localize the electrodes in the sub-thalamic nucleus in Parkinson's disease (PD) patients using the stimulation artifact during deep brain stimulation. The source analysis method used here is the dynamic imaging of coherent sources (DICS) ( Gross et al. 2001 ) with a realistic boundary element method forward model ( Fuchs et al. 2002 ). The second aim was to find out which of the modalities, electroencephalography (EEG), magnetoencephalography (MEG) or the combined approach is precise in estimating the localization of the electrodes. Main conclusion The source analysis method was able to localize the subthalamic nucleus in all the patients using the artifact induced by the deep brain stimulation. The combined approach could be very efficient in localizing the electrodes in the subthalamic nucleus compared to the individual modalities. The localization of the electrodes is an excellent approach for the validation of theBackground / Purpose The first aim of this study was to localize the electrodes in the sub-thalamic nucleus in Parkinson's disease (PD) patients using the stimulation artifact during deep brain stimulation. The source analysis method used here is the dynamic imaging of coherent sources (DICS) ( Gross et al. 2001 ) with a realistic boundary element method forward model ( Fuchs et al. 2002 ). The second aim was to find out which of the modalities, electroencephalography (EEG), magnetoencephalography (MEG) or the combined approach is precise in estimating the localization of the electrodes. Main conclusion The source analysis method was able to localize the subthalamic nucleus in all the patients using the artifact induced by the deep brain stimulation. The combined approach could be very efficient in localizing the electrodes in the subthalamic nucleus compared to the individual modalities. The localization of the electrodes is an excellent approach for the validation of the applied source analysis method and to test which is the best modality in such applications.…