Open Access

Muthuraman Muthuraman, Abdul Rauf Anwar, Kidist Gebremariam Mideksa, Jan Raethjen, Günther Deuschl

• Background / Purpose The aim of this study was to identify if cross frequency coupling is present in Parkinson's disease (PD) patients during the ON state of deep brain stimulator (DBS). Also, to understand the influence of the DBS frequency on other frequency oscillations present in the brain of the PD patients. The source analysis method used here is the dynamic imaging of coherent sources (DICS) ( Gross et al . 2001 ) with a realistic boundary element method forward model ( Fuchs et al. 2002 ). Finally, to describe the cross frequency coupling in the identified sources using the measure frequency to frequency coupling ( Jirsa et al. 2013 ). Main conclusion The source analysis revealed the networks influenced during the deep brain simulation in the PD patients. The existing frequency-frequency coupling revealed that this could be one reason in solving a larger puzzle of why deep brain stimulation affects only the involuntary and not the voluntary actions in the PD patients.