Locating the STN-DBS electrodes and resolving their subsequent networks using coherent source analysis on EEG

  • The deep brain stimulation (DBS) of the subthalamic nucleus (STN) is the most effective surgical therapy for Parkinson's disease (PD). The first aim of the study was to locate the STN-DBS electrode by applying source analysis on EEG. Secondly, to identify tremor related areas which are associated with the STN. The Dynamic imaging of coherent sources (DICS) was used to find the coherent sources in the brain. The capability of the source analysis to detect deep sources like STN in the brain using EEG data was tested with two model dipole simulations. The simulations were concentrated on two aspects, the angle of the dipole orientation and the disturbance of the cortical areas on locating subcortical regions. In all the DBS treated Parkinsonian tremor patients the power spectrum showed a clear peak at the stimulated frequency and followed by there harmonics. The DBS stimulated frequency constituted a network of primary sensory motor cortex, supplementary motor area, prefrontal cortex,The deep brain stimulation (DBS) of the subthalamic nucleus (STN) is the most effective surgical therapy for Parkinson's disease (PD). The first aim of the study was to locate the STN-DBS electrode by applying source analysis on EEG. Secondly, to identify tremor related areas which are associated with the STN. The Dynamic imaging of coherent sources (DICS) was used to find the coherent sources in the brain. The capability of the source analysis to detect deep sources like STN in the brain using EEG data was tested with two model dipole simulations. The simulations were concentrated on two aspects, the angle of the dipole orientation and the disturbance of the cortical areas on locating subcortical regions. In all the DBS treated Parkinsonian tremor patients the power spectrum showed a clear peak at the stimulated frequency and followed by there harmonics. The DBS stimulated frequency constituted a network of primary sensory motor cortex, supplementary motor area, prefrontal cortex, diencephalon, cerebellum and brainstem. Thus the STN was located in the region of the diencephalon. The resolved network may give better understanding to the pathophysiology of the effected tremor network in PD patients with STN-DBS.show moreshow less

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Metadaten
Author:Muthuraman MuthuramanORCiDGND, S. Paschen, H. Hellriegel, Sergiu Groppa, Günther Deuschl, Jan Raethjen
URN:urn:nbn:de:bvb:384-opus4-1103505
Frontdoor URLhttps://opus.bibliothek.uni-augsburg.de/opus4/110350
ISBN:978-1-4244-4119-8OPAC
Parent Title (English):2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 28 August - 1 September 2012, San Diego, CA, USA
Publisher:IEEE
Place of publication:Piscataway, NJ
Editor:Michael C. K. Khoo
Type:Conference Proceeding
Language:English
Year of first Publication:2012
Publishing Institution:Universität Augsburg
Release Date:2023/12/21
First Page:3970
Last Page:3973
DOI:https://doi.org/10.1109/embc.2012.6346836
Institutes:Fakultät für Angewandte Informatik
Fakultät für Angewandte Informatik / Institut für Informatik
Fakultät für Angewandte Informatik / Institut für Informatik / Professur für Informatik in der Medizintechnik
Dewey Decimal Classification:0 Informatik, Informationswissenschaft, allgemeine Werke / 00 Informatik, Wissen, Systeme / 004 Datenverarbeitung; Informatik
Licence (German):Deutsches Urheberrecht