Dopamine D2 receptor antagonism of antipsychotics and the risk of death due to choking

  • The risk of fatal choking for people with schizophrenia and associations with antipsychotic medication are largely unknown. Therefore, we calculated the choking-related standardized mortality ratio for schizophrenia relative to the general population (SMRchoking) and adjusted hazard ratios (aHR) of choking-related mortality for antipsychotics in a nationwide cohort of patients with schizophrenia (N=59,916). SMRchoking was 20.5 (95% confidence interval (CI)=17.1–23.9). The aHR was 1.74 (95%CI=1.19–2.55) for strong dopamine 2-antagonists. For other antipsychotics, CIs included 1. Importantly, aHRs were particularly high for high dose categories of strong dopamine 2-antagonists. In conclusion, a schizophrenia diagnosis is associated with a 20-fold risk of death due to choking. This risk is elevated during use of strong dopamine 2-antagonist antipsychotics, particularly when prescribed in high dosages.

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Author:Jurjen J. Luykx, Antti Tanskanen, Markku Lähteenvuo, Peter Manu, Christoph U. Correll, Alkomiet HasanORCiDGND, Johannes Lieslehto, Heidi Taipale, Jari Tiihonen
Frontdoor URL
Parent Title (English):Psychiatry Research
Publisher:Elsevier BV
Year of first Publication:2024
Publishing Institution:Universität Augsburg
Release Date:2024/06/14
First Page:116012
Institutes:Medizinische Fakultät
Medizinische Fakultät / Lehrstuhl für Psychiatrie und Psychotherapie
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Latest Publications (not yet published in print):Aktuelle Publikationen (noch nicht gedruckt erschienen)
Licence (German):CC-BY 4.0: Creative Commons: Namensnennung (mit Print on Demand)