Dopamine D2 receptor antagonism of antipsychotics and the risk of death due to choking
- The risk of fatal choking for people with schizophrenia and associations with antipsychotic medication are largely unknown. Therefore, we calculated the choking-related standardized mortality ratio for schizophrenia relative to the general population (SMRchoking) and adjusted hazard ratios (aHR) of choking-related mortality for antipsychotics in a nationwide cohort of patients with schizophrenia (N=59,916). SMRchoking was 20.5 (95% confidence interval (CI)=17.1–23.9). The aHR was 1.74 (95%CI=1.19–2.55) for strong dopamine 2-antagonists. For other antipsychotics, CIs included 1. Importantly, aHRs were particularly high for high dose categories of strong dopamine 2-antagonists. In conclusion, a schizophrenia diagnosis is associated with a 20-fold risk of death due to choking. This risk is elevated during use of strong dopamine 2-antagonist antipsychotics, particularly when prescribed in high dosages.
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| Author: | Jurjen J. Luykx, Antti Tanskanen, Markku Lähteenvuo, Peter Manu, Christoph U. Correll, Alkomiet HasanORCiDGND, Johannes Lieslehto, Heidi Taipale, Jari Tiihonen |
|---|---|
| URN: | urn:nbn:de:bvb:384-opus4-1134632 |
| Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/113463 |
| ISSN: | 0165-1781OPAC |
| Parent Title (English): | Psychiatry Research |
| Publisher: | Elsevier BV |
| Type: | Article |
| Language: | English |
| Year of first Publication: | 2024 |
| Publishing Institution: | Universität Augsburg |
| Release Date: | 2024/06/14 |
| Volume: | 339 |
| First Page: | 116012 |
| DOI: | https://doi.org/10.1016/j.psychres.2024.116012 |
| Institutes: | Medizinische Fakultät |
| Medizinische Fakultät / Lehrstuhl für Psychiatrie und Psychotherapie | |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Licence (German): |  CC-BY 4.0: Creative Commons: Namensnennung (mit Print on Demand) |
