The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons
- Clonally expanded mitochondrial DNA (mtDNA) deletions accumulate with age in human substantia nigra (SN) and high levels cause respiratory chain deficiency. In other human tissues, mtDNA point mutations clonally expand with age. Here, the abundance of mtDNA point mutations within single SN neurons from aged controls was investigated. From 31 single cytochrome c oxidase normal SN neurons, only one clonally expanded mtDNA point mutation was identified, suggesting in these neurons mtDNA point mutations occur rarely, whereas mtDNA deletions are frequently observed. This contrasts observations in mitotic tissues and suggests that different forms of mtDNA maintenance may exist in these two cell types.
| Author: | Amy K. Reeve, Kim J. Krishnan, Geoffrey Taylor, Joanna L. Elson, Andreas BenderGND, Robert W. Taylor, Christopher M. Morris, Doug M. Turnbull |
|---|---|
| URN: | urn:nbn:de:bvb:384-opus4-1139738 |
| Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/113973 |
| ISSN: | 1474-9718OPAC |
| ISSN: | 1474-9726OPAC |
| Parent Title (English): | Aging Cell |
| Publisher: | Wiley |
| Place of publication: | Weinheim |
| Type: | Article |
| Language: | English |
| Year of first Publication: | 2009 |
| Publishing Institution: | Universität Augsburg |
| Release Date: | 2024/07/11 |
| Volume: | 8 |
| Issue: | 4 |
| First Page: | 496 |
| Last Page: | 498 |
| DOI: | https://doi.org/10.1111/j.1474-9726.2009.00492.x |
| Institutes: | Medizinische Fakultät |
| Medizinische Fakultät / Lehrstuhl für Neurorehabilitation | |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Licence (German): |  Sonstige Open-Access-Lizenz |
