Continuous and label-free microfluidic cell separation

  • Using size and deformability as intrinsic biomarkers, we separate red blood cells (RBC) from other blood components based on the non-inertial lift effect. We exploit this purely viscous, repulsive cell-wall interaction at low Reynolds numbers to induce a lateral migration of soft objects perpendicular to the streamlines of the fluid which closely follows theoretical prediction by Olla [1]. We demonstrate the separation of RBCs, blood platelets, solid microspheres, and circulating MV3-melanoma cells and study the influence of the flow rate on the separation. The method can be used for passive, continuous and label-free cell classification in on-chip blood analysis.

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Metadaten
Author:Thomas M. Geislinger, Benjamin Eggart, Susanne Braunmüller, L. Schmid, Thomas FrankeGND
Frontdoor URLhttps://opus.bibliothek.uni-augsburg.de/opus4/117011
URL:https://www.rsc.org/images/loc/2013/PDFs/Papers/335_0791.pdf
ISBN:978-1-63266-624-6OPAC
Parent Title (English):17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 27-31 October 2013, Freiburg, Germany
Publisher:Chemical and Biological Microsystems Society (CBMS)
Place of publication:San Diego, CA
Editor:Roland Zengerle, Andreas Manz, Petra Schwille, Holger Becker
Type:Conference Proceeding
Language:English
Year of first Publication:2013
Release Date:2024/11/25
Issue:volume 2
First Page:1000
Last Page:1002
Institutes:Mathematisch-Naturwissenschaftlich-Technische Fakultät
Mathematisch-Naturwissenschaftlich-Technische Fakultät / Institut für Physik
Mathematisch-Naturwissenschaftlich-Technische Fakultät / Institut für Physik / Lehrstuhl für Experimentalphysik I
Nachhaltigkeitsziele
Nachhaltigkeitsziele / Ziel 3 - Gesundheit und Wohlergehen
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik

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