A new fibrin-heparine coated self-expanding stent for the rescue treatment of intracranial stenosis — a multicentric study

  • Introduction Rescue intracranial stenting is necessary to provide sufficient recanalization after mechanical thrombectomy (MT) in patients with acute large vessel occlusions (LVO) due to an underlying intracranial atherosclerotic disease (ICAD). The CREDO heal is a novel stent that provides a potentially lower thrombogenicity due to surface modification. We present the first multicentric experience with the CREDO heal for acute rescue stenting. Methods Data of 81 patients who underwent rescue stenting after MT at 12 centers in Germany and Spain were prospectively collected and retrospectively evaluated. Results Final mTICI 2b‑3 was reached in 95.1% after median two MT maneuvers and stenting. Four periprocedural complications resulted in clinical deterioration (4.9%). Intraparenchymal hemorrhage occurred in one patient (1.2%) and functional independence at FU was reached by 42% of the patients. Most interventions were performed under Gp IIb/IIIaIntroduction Rescue intracranial stenting is necessary to provide sufficient recanalization after mechanical thrombectomy (MT) in patients with acute large vessel occlusions (LVO) due to an underlying intracranial atherosclerotic disease (ICAD). The CREDO heal is a novel stent that provides a potentially lower thrombogenicity due to surface modification. We present the first multicentric experience with the CREDO heal for acute rescue stenting. Methods Data of 81 patients who underwent rescue stenting after MT at 12 centers in Germany and Spain were prospectively collected and retrospectively evaluated. Results Final mTICI 2b‑3 was reached in 95.1% after median two MT maneuvers and stenting. Four periprocedural complications resulted in clinical deterioration (4.9%). Intraparenchymal hemorrhage occurred in one patient (1.2%) and functional independence at FU was reached by 42% of the patients. Most interventions were performed under Gp IIb/IIIa inhibitors. Conclusion CREDO heal was effective and safe in our case series. However, more data is needed to define the optimal antithrombotic regime. The use under single antiplatelet medication is not supported by our study.show moreshow less

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Author:Franziska Dorn, Yves Leonard Voss, Mousa Zidan, Stephanie Neuhaus, Nils Lehnen, Paul Stracke, Wolfram Schwindt, Mostafa Ergawy, Christian Dyzmann, Markus Moehlenbruch, Jessica Jesser, Dominik Vollherbst, Manuel Moreu, Carlos Pérez-García, Maxim Bester, Fabian Flottmann, Andreas Simgen, Stefan Schob, Ansgar BerlisORCiDGND, Christoph MaurerORCiDGND, Jan Hendrik Buhk, Hannah Hentschel, Christian Loehr, Bernd Eckert, Javier Saura, Fernando Delgado, Daniel Paech, Hannes Nordmeyer
URN:urn:nbn:de:bvb:384-opus4-1196438
Frontdoor URLhttps://opus.bibliothek.uni-augsburg.de/opus4/119643
ISSN:1869-1439OPAC
ISSN:1869-1447OPAC
Parent Title (English):Clinical Neuroradiology
Publisher:Springer Science and Business Media LLC
Type:Article
Language:English
Year of first Publication:2025
Publishing Institution:Universität Augsburg
Release Date:2025/03/18
Volume:35
Issue:1
First Page:43
Last Page:50
DOI:https://doi.org/10.1007/s00062-024-01448-6
Institutes:Medizinische Fakultät
Medizinische Fakultät / Universitätsklinikum
Medizinische Fakultät / Lehrstuhl für Diagnostische und Interventionelle Neuroradiologie
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):CC-BY 4.0: Creative Commons: Namensnennung (mit Print on Demand)