Open Access

Giuliano Filippini Velazquez

• Background: Resection of liver metastases from colorectal cancer (CRC) in the oligometastatic stage improves survival and is a potentially curative treatment. Thus, predictive scores that reliable identify those patients who especially benefit from surgery are essential. Methods: In this multicenter analysis, 512 patients had undergone surgery for liver metastases from CRC. We investigated distinct cancer-specific risk factors that are routinely available in clinical practice and developed a predictive preoperative score using a training cohort (TC), which was thereafter tested in a validation cohort (VC). Results: Inflammatory response to the tumor, a right-sided primary tumor, multiple liver metastases and node-positive primary tumor were significant adverse variables for overall survival (OS). Patients were stratified according to the cumulative score given by the presence of these risk factors in 5 groups. Median OS for patients without risk factors was 133.8 months (CI 95%:Background: Resection of liver metastases from colorectal cancer (CRC) in the oligometastatic stage improves survival and is a potentially curative treatment. Thus, predictive scores that reliable identify those patients who especially benefit from surgery are essential. Methods: In this multicenter analysis, 512 patients had undergone surgery for liver metastases from CRC. We investigated distinct cancer-specific risk factors that are routinely available in clinical practice and developed a predictive preoperative score using a training cohort (TC), which was thereafter tested in a validation cohort (VC). Results: Inflammatory response to the tumor, a right-sided primary tumor, multiple liver metastases and node-positive primary tumor were significant adverse variables for overall survival (OS). Patients were stratified according to the cumulative score given by the presence of these risk factors in 5 groups. Median OS for patients without risk factors was 133.8 months (CI 95%: 81.2–nr) in the TC and was not reached in the VC. OS decreased significantly for each subsequent group with increasing number of risk factors. Median OS was significantly shorter (p<0.0001) for patients presenting all four risk factors: 14.3 months (CI 95%: 10.5-nr) in the TC and 16.6 months (CI 95%: 14.6-nr) in the VC. Conclusion: Including easily obtainable variables, this preoperative score distinguishes oligometastatic CRC patients with prolonged survival rates that may be cured, and harbors potential to be implemented in daily clinical practice.…