Chiral separation in microflows

  • Molecules that only differ by their chirality, so called enantiomers, often possess different properties with respect to their biological function. Therefore, the separation of enantiomers presents a prominent challenge in molecular biology and belongs to the ``Holy Grail'' of organic chemistry. We suggest a new separation technique for chiral molecules that is based on the transport properties in a microfluidic flow with spatially variable vorticity. Because of their size the thermal fluctuating motion of the molecules must be taken into account. These fluctuations play a decisive role in the proposed separation mechanism.

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Author:Marcin KosturGND, Michael SchindlerGND, Peter TalknerGND, Peter HänggiGND
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Publishing Institution:Universität Augsburg
Release Date:2006/08/31
Tag:separation; chirality; isomerism; molecular biophysics; microfluidics; vortices; fluctuations
GND-Keyword:Chiralität <Elementarteilchenphysik>; Isomer; Molekulare Biophysik; Trennverfahren
Source:erschienen in: Phys. Rev. Lett. 96, 014502 (2006); DOI: 10.1103/PhysRevLett.96.014502; URL:
Institutes:Mathematisch-Naturwissenschaftlich-Technische Fakultät
Mathematisch-Naturwissenschaftlich-Technische Fakultät / Institut für Physik
Mathematisch-Naturwissenschaftlich-Technische Fakultät / Institut für Physik / Lehrstuhl für Theoretische Physik I
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik