Effect of channel block on the spiking activity of excitable membranes in a stochastic Hodgkin-Huxley model

  • The influence of intrinsic channel noise on the spontaneous spiking activity of poisoned excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model. Internal noise stemming from the stochastic dynamics of individual ion channels is known to affect the collective properties of the whole ion channel cluster. For example, there exists an optimal size of the membrane patch for which the internal noise alone causes a regular spontaneous generation of action potentials. In addition to varying the size of ion channel clusters, living organisms may adapt the densities of ion channels in order to optimally regulate the spontaneous spiking activity. The influence of channel block on the excitability of a membrane patch of certain size is twofold: First, a variation of ion channel densities primarily yields a change of the conductance level. Second, a down-regulation of working ion channels always increases the channel noise. While the former effectThe influence of intrinsic channel noise on the spontaneous spiking activity of poisoned excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model. Internal noise stemming from the stochastic dynamics of individual ion channels is known to affect the collective properties of the whole ion channel cluster. For example, there exists an optimal size of the membrane patch for which the internal noise alone causes a regular spontaneous generation of action potentials. In addition to varying the size of ion channel clusters, living organisms may adapt the densities of ion channels in order to optimally regulate the spontaneous spiking activity. The influence of channel block on the excitability of a membrane patch of certain size is twofold: First, a variation of ion channel densities primarily yields a change of the conductance level. Second, a down-regulation of working ion channels always increases the channel noise. While the former effect dominates in the case of sodium channel block resulting in a reduced spiking activity, the latter enhances the generation of spontaneous action potentials in the case of a tailored potassium channel blocking. Moreover, by blocking some portion of either potassium or sodium ion channels, it is possible to either increase or to decrease the regularity of the spike train.show moreshow less

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Metadaten
Author:Gerhard SchmidGND, Igor GoychukORCiDGND, Peter HänggiORCiDGND
URN:urn:nbn:de:bvb:384-opus4-2915
Frontdoor URLhttps://opus.bibliothek.uni-augsburg.de/opus4/357
Type:Preprint
Language:English
Publishing Institution:Universität Augsburg
Release Date:2006/09/07
Tag:channel noise; spiking activity; stochastic Hodgkin-Huxley model; membrane
GND-Keyword:Ionenkanal; Rauschen; Ionentheorie der Erregung; Membran; Stochastisches Modell
Source:erschienen in: Physical Biology 1, 61–66 (2004); DOI: 10.1088/1478-3967/1/2/002; URL: http://www.iop.org/EJ/abstract/1478-3975/1/2/002/
Institutes:Mathematisch-Naturwissenschaftlich-Technische Fakultät
Mathematisch-Naturwissenschaftlich-Technische Fakultät / Institut für Physik
Mathematisch-Naturwissenschaftlich-Technische Fakultät / Institut für Physik / Lehrstuhl für Theoretische Physik I
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik