CXCR4-directed theranostics in oncology and inflammation
- Given its prominent role in inflammation and cancer biology, the C-X-C motif chemokine receptor 4 (CXCR4) has gained a lot of attention in the recent years. This review gives a short overview of the physiology and pathology of chemokines and chemokine receptors and then focuses on the current experience of targeting CXCR4, using radiolabeled receptor ligands suitable for positron emission tomography (PET) imaging, in both hematologic and solid malignancy as well as in inflammatory conditions. Additionally, CXCR4-directed endoradiotherapy (ERT) as a new treatment option is discussed.
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| Author: | Malte Kircher, Peter Herhaus, Margret Schottelius, Andreas K. Buck, Rudolf A. Werner, Hans-Jürgen Wester, Ulrich Keller, Constantin LapaORCiDGND |
|---|---|
| URN: | urn:nbn:de:bvb:384-opus4-629914 |
| Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/62991 |
| ISSN: | 0914-7187OPAC |
| ISSN: | 1864-6433OPAC |
| Parent Title (English): | Annals of Nuclear Medicine |
| Publisher: | Springer |
| Place of publication: | Berlin |
| Type: | Article |
| Language: | English |
| Year of first Publication: | 2018 |
| Publishing Institution: | Universität Augsburg |
| Release Date: | 2019/10/01 |
| Tag: | General Medicine; Radiology Nuclear Medicine and imaging |
| Volume: | 32 |
| Issue: | 8 |
| First Page: | 503 |
| Last Page: | 511 |
| DOI: | https://doi.org/10.1007/s12149-018-1290-8 |
| Institutes: | Medizinische Fakultät |
| Medizinische Fakultät / Universitätsklinikum | |
| Medizinische Fakultät / Lehrstuhl für Nuklearmedizin | |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Licence (German): |  CC-BY 4.0: Creative Commons: Namensnennung |
