Open Access

C. Fodi, M. Skardelly, S. Castaneda, G. Tabatabai, J. Honegger, M. Tatagiba, J. Schittenhelm, Felix Behling

• Background: The expression of somatostatin receptors in meningioma is well established. First suggestions of a prognostic impact of SSTRs in meningioma have also been made. However, the knowledge is based on few investigations in small cohorts. We recently analyzed the expression of all five known SSTRs in a large cohort of over 700 meningiomas and showed correlations with WHO tumor grade and other clinical characteristics. Methods: We therefore expanded our dataset and collected information about radiographic tumor recurrence and progression as well as other established prognostic factors for a comprehensive prognostic multivariate analysis (gender, age, primary/recurrent tumor, extent of resection (Simpson grade), WHO grade, adjuvant radiotherapy and confirmed neurofibromatosis type 2) . Results: Male gender, recurrent tumor, incomplete resection (Simpson grade 4) and higher WHO grade (II or III) were independent negative prognostic factors for tumor recurrence while adjuvantBackground: The expression of somatostatin receptors in meningioma is well established. First suggestions of a prognostic impact of SSTRs in meningioma have also been made. However, the knowledge is based on few investigations in small cohorts. We recently analyzed the expression of all five known SSTRs in a large cohort of over 700 meningiomas and showed correlations with WHO tumor grade and other clinical characteristics. Methods: We therefore expanded our dataset and collected information about radiographic tumor recurrence and progression as well as other established prognostic factors for a comprehensive prognostic multivariate analysis (gender, age, primary/recurrent tumor, extent of resection (Simpson grade), WHO grade, adjuvant radiotherapy and confirmed neurofibromatosis type 2) . Results: Male gender, recurrent tumor, incomplete resection (Simpson grade 4) and higher WHO grade (II or III) were independent negative prognostic factors for tumor recurrence while adjuvant radiotherapy was an independen positive prognostic factor (p=0.0012). An increased expression of SSTR2A was revealed as an independent negative prognostic factor for tumor recurrence (p=0.0239). A higher expression of SSTR5 was associated with a better prognosis (p=0.0024). Conclusion: While an increased expression of SSTR2A is a negative prognostic factor for tumor recurrence, a higher expression of SSTR5 has a protective effect.…