Eric M. Tam, Ross B. Fulton, James F. Sampson, Marco Muda, Adam Camblin, Jennifer Richards, Alexander Koshkaryev, Jian Tang, Vinodh Kurella, Yang Jiao, Lihui Xu, Kathy Zhang, Neeraj Kohli, Lia Luus, Elizabeth Hutto, Sandeep Kumar, James Lulo, Violette Paragas, Christina Wong, James Suchy, Stephanie Grabow, Anne-Sophie Dugast, Hong Zhang, Fabien Depis, Sonia Feau, Aniela Jakubowski, Wenlian Qiao, Galina Craig, Maja Razlog, James Qiu, Yu Zhou, James D. Marks, Michael Croft, Daryl C. Drummond, Andreas Raue
- Tumor necrosis factor receptor 2 (TNFR2) is the alternate receptor for TNF and can mediate both pro- and anti-inflammatory activities of T cells. Although TNFR2 has been linked to enhanced suppressive activity of regulatory T cells (Tregs) in autoimmune diseases, the viability of TNFR2 as a target for cancer immunotherapy has been underappreciated. Here, we show that new murine monoclonal anti-TNFR2 antibodies yield robust antitumor activity and durable protective memory in multiple mouse cancer cell line models. The antibodies mediate potent Fc-dependent T cell costimulation and do not result in significant depletion of Tregs. Corresponding human agonistic monoclonal anti-TNFR2 antibodies were identified and also had antitumor effects in humanized mouse models. Anti-TNFR2 antibodies could be developed as a novel treatment option for patients with cancer.
Metadaten| Author: | Eric M. Tam, Ross B. Fulton, James F. Sampson, Marco Muda, Adam Camblin, Jennifer Richards, Alexander Koshkaryev, Jian Tang, Vinodh Kurella, Yang Jiao, Lihui Xu, Kathy Zhang, Neeraj Kohli, Lia Luus, Elizabeth Hutto, Sandeep Kumar, James Lulo, Violette Paragas, Christina Wong, James Suchy, Stephanie Grabow, Anne-Sophie Dugast, Hong Zhang, Fabien Depis, Sonia Feau, Aniela Jakubowski, Wenlian Qiao, Galina Craig, Maja Razlog, James Qiu, Yu Zhou, James D. Marks, Michael Croft, Daryl C. Drummond, Andreas RaueORCiDGND |
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| URN: | urn:nbn:de:bvb:384-opus4-1130603 |
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| Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/113060 |
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| ISSN: | 1946-6234OPAC |
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| ISSN: | 1946-6242OPAC |
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| Parent Title (English): | Science Translational Medicine |
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| Publisher: | American Association for the Advancement of Science (AAAS) |
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| Place of publication: | Washington, DC |
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| Type: | Article |
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| Language: | English |
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| Year of first Publication: | 2019 |
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| Publishing Institution: | Universität Augsburg |
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| Release Date: | 2024/05/21 |
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| Volume: | 11 |
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| Issue: | 512 |
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| First Page: | eaax0720 |
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| DOI: | https://doi.org/10.1126/scitranslmed.aax0720 |
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| Institutes: | Fakultät für Angewandte Informatik |
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| Fakultät für Angewandte Informatik / Institut für Informatik |
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| Fakultät für Angewandte Informatik / Institut für Informatik / Lehrstuhl für Modellierung und Simulation biologischer Prozesse |
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| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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| Licence (German): |  Deutsches Urheberrecht |
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