Miriam Gruhle, Brigitte Bison, Katharina Gastberger, Pascal D. Johann, Irene Teichert von Lüttichau, Marc Steinborn, Stephan Tippelt, Gudrun Fleischhack, Thomas Lehrnbecher, Reiner Siebert, Stefanie E. Tüchert‐Knoll, Patrick Melchior, Christian Vokuhl, Wolfgang Hartmann, Martin Hasselblatt, Michael C. Frühwald
- Background: Malignant rhabdoid tumors occasionally develop along cranial nerves, but clinical, histopathological, and
molecular features have not been examined in larger series.
Procedure: We retrospectively interrogated data from the European Rhabdoid Registry, EU-RHAB, to identify malignant rhabdoid
tumors affecting cranial nerves. We retrieved clinical information and reviewed magnetic resonance imaging (MRI) data.
Furthermore, histopathological review and molecular profiling were performed.
Results: Among 425 patients, we identified a total of 14 harboring malignant rhabdoid tumors with cranial nerve involvement.
Median age at diagnosis was 28 months (range: 0–13 years). Various cranial nerves were affected, the trigeminal nerve (n =
4) and the facial and/or vestibulocochlear nerve (n = 5) being most frequently involved. In most cases, the initial clinical and
neuroradiological suspicion was schwannoma. Neuroradiology review of magnetic resonance imaging studies confirmed aBackground: Malignant rhabdoid tumors occasionally develop along cranial nerves, but clinical, histopathological, and
molecular features have not been examined in larger series.
Procedure: We retrospectively interrogated data from the European Rhabdoid Registry, EU-RHAB, to identify malignant rhabdoid
tumors affecting cranial nerves. We retrieved clinical information and reviewed magnetic resonance imaging (MRI) data.
Furthermore, histopathological review and molecular profiling were performed.
Results: Among 425 patients, we identified a total of 14 harboring malignant rhabdoid tumors with cranial nerve involvement.
Median age at diagnosis was 28 months (range: 0–13 years). Various cranial nerves were affected, the trigeminal nerve (n =
4) and the facial and/or vestibulocochlear nerve (n = 5) being most frequently involved. In most cases, the initial clinical and
neuroradiological suspicion was schwannoma. Neuroradiology review of magnetic resonance imaging studies confirmed a tumor…
