An acoustically-driven biochip: particle-cell interactions under physiological flow conditions [Abstract]
- Introduction: The interaction of particulate drug carriers with cells has generally been assessed in stationary microplate assays. These setups fail to reflect the flow conditions in vivo which generate substantial hydrodynamic drag forces [1]. In order to address this shortcoming, a microfluidic biochip with the capability of imitating a wide range of shear rates and pulsation modes has been developed. This device, which is based on an incorporated surface acoustic wave pump, was used to study the interaction of targeted microparticles with epithelial cells under flow conditions.
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| Author: | C. Fillafer, G. Ratzinger, J. Neumann, S. Dissauer, M. Wirth, F. Gabor, Matthias F. Schneider |
|---|---|
| URN: | urn:nbn:de:bvb:384-opus4-1029065 |
| Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/102906 |
| ISSN: | 0036-8709OPAC |
| Parent Title (Uncoded Languages): | Scientia Pharmaceutica |
| Publisher: | MDPI |
| Type: | Article |
| Language: | English |
| Year of first Publication: | 2009 |
| Publishing Institution: | Universität Augsburg |
| Release Date: | 2023/04/07 |
| Tag: | Pharmaceutical Science |
| Volume: | 77 |
| Issue: | 1 |
| First Page: | 178 |
| DOI: | https://doi.org/10.3797/scipharm.oephg.21.sl-11 |
| Institutes: | Mathematisch-Naturwissenschaftlich-Technische Fakultät |
| Mathematisch-Naturwissenschaftlich-Technische Fakultät / Institut für Physik | |
| Mathematisch-Naturwissenschaftlich-Technische Fakultät / Institut für Physik / Lehrstuhl für Experimentalphysik I | |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik |
| Licence (German): |  CC-BY-NC-ND 4.0: Creative Commons: Namensnennung - Nicht kommerziell - Keine Bearbeitung (mit Print on Demand) |
