Changes in functional capacity after endoscopic lung volume reduction in patients with chronic obstructive lung disease and severe emphysema

  • Objective: To evaluate changes in functional capacity after endoscopic lung volume reduction (ELVR) in patients with chronic obstructive lung disease (COPD) and severe emphysema. Methods: Lung function and cardio-pulmonary exercise testing were performed before and three month after ELVR. The extent of LVR was evaluated by high resolution computed tomography (HR-CT) before and 3 month after ELVR. Eight patients with substantial LVR or complete atelectasis were compared with eight subjects without relevant LVR on HR-CT scans by linear regression analysis. Results: Relevant LVR significantly predicts a reduction of total lung capacity (p = 0.046) and residual volume (p = 0.007), an improvement of the oxygen equivalent at rest (p = 0.044) and at peak exercise (p = 0.025), a reduction in alveolar-arterial oxygen difference at rest (p = 0.007), a reduction of the slope of minute ventilation to carbon dioxide output (p = 0.048) and an improvement of the respiratory quotient (p =Objective: To evaluate changes in functional capacity after endoscopic lung volume reduction (ELVR) in patients with chronic obstructive lung disease (COPD) and severe emphysema. Methods: Lung function and cardio-pulmonary exercise testing were performed before and three month after ELVR. The extent of LVR was evaluated by high resolution computed tomography (HR-CT) before and 3 month after ELVR. Eight patients with substantial LVR or complete atelectasis were compared with eight subjects without relevant LVR on HR-CT scans by linear regression analysis. Results: Relevant LVR significantly predicts a reduction of total lung capacity (p = 0.046) and residual volume (p = 0.007), an improvement of the oxygen equivalent at rest (p = 0.044) and at peak exercise (p = 0.025), a reduction in alveolar-arterial oxygen difference at rest (p = 0.007), a reduction of the slope of minute ventilation to carbon dioxide output (p = 0.048) and an improvement of the respiratory quotient (p = 0.017). Conclusion: Successful ELVR significantly predicts improvements in functional capacity in patients with COPD and severe emphysema.show moreshow less

Export metadata

Statistics

Number of document requests

Additional Services

Share in Twitter Search Google Scholar
Metadaten
Author:Fabian Geissenberger, Stefanie Bader, Christian Faul, Martin Schwaiblmair, Thomas Berghaus
Frontdoor URLhttps://opus.bibliothek.uni-augsburg.de/opus4/76806
Parent Title (English):Interventional Pulmonology
Publisher:European Respiratory Society
Type:Article
Language:English
Year of first Publication:2018
Release Date:2020/06/11
Volume:52
Issue:Supplement 62
First Page:PA5401
DOI:https://doi.org/10.1183/13993003.congress-2018.pa5401
Institutes:Medizinische Fakultät
Medizinische Fakultät / Universitätsklinikum
Medizinische Fakultät / Lehrstuhl für Innere Medizin mit Schwerpunkt Kardiologie