NF-κB and its role in checkpoint control
- Nuclear factor-κB (NF-κB) has been described as one of the most important molecules linking inflammation to cancer. More recently, it has become clear that NF-κB is also involved in the regulation of immune checkpoint expression. Therapeutic approaches targeting immune checkpoint molecules, enabling the immune system to initiate immune responses against tumor cells, constitute a key breakthrough in cancer treatment. This review discusses recent evidence for an association of NF-κB and immune checkpoint expression and examines the therapeutic potential of inhibitors targeting either NF-κB directly or molecules involved in NF-κB regulation in combination with immune checkpoint blockade.
| Author: | Annika C. Betzler, Marie-Nicole Theodoraki, Patrick J. Schuler, Johannes DöscherORCiDGND, Simon Laban, Thomas K. Hoffmann, Cornelia Brunner |
|---|---|
| URN: | urn:nbn:de:bvb:384-opus4-1013950 |
| Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/101395 |
| ISSN: | 1422-0067OPAC |
| Parent Title (English): | International Journal of Molecular Sciences |
| Publisher: | MDPI AG |
| Type: | Article |
| Language: | English |
| Year of first Publication: | 2020 |
| Publishing Institution: | Universität Augsburg |
| Release Date: | 2023/01/30 |
| Tag: | Catalysis; Computer Science Applications; General Medicine; Inorganic Chemistry; Molecular Biology; Organic Chemistry; Physical and Theoretical Chemistry; Spectroscopy |
| Volume: | 21 |
| Issue: | 11 |
| First Page: | 3949 |
| DOI: | https://doi.org/10.3390/ijms21113949 |
| Institutes: | Medizinische Fakultät |
| Medizinische Fakultät / Universitätsklinikum | |
| Medizinische Fakultät / Lehrstuhl für Hals-, Nasen- und Ohrenheilkunde | |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Licence (German): |  CC-BY 4.0: Creative Commons: Namensnennung |
