Translation of functional domain abnormalities from human to mouse motor system
- Multiple sclerosis (MS) is characterized by frequent impairment of motor skills, with the most prominent manifestations being spasticity, gait impairment, fatigue, or disabling tremor, all highly important determinants of physical disability. The optimization of the reverse translation from humans to mice of relevant readouts of abnormal motor function could definitively improve actual models of neuroinflammation to better match human functional outcomes in MS patients. The aim of this chapter is to provide a descriptive methodological framework to approach human motor function abnormalities that could ground a translational pathway from patients to mice.
| Author: | Muthuraman MuthuramanORCiDGND, Dumitru Ciolac, Venkata Chaitanya Chirumamilla |
|---|---|
| Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/109793 |
| ISBN: | 9781071612125OPAC |
| ISBN: | 9781071612132OPAC |
| ISSN: | 0893-2336OPAC |
| ISSN: | 1940-6045OPAC |
| Parent Title (English): | Translational methods for multiple sclerosis research |
| Publisher: | Humana |
| Place of publication: | New York, NY |
| Editor: | Sergiu Groppa, Sven G. Meuth |
| Type: | Part of a Book |
| Language: | English |
| Year of first Publication: | 2021 |
| Release Date: | 2023/12/06 |
| First Page: | 139 |
| Last Page: | 152 |
| Series: | Neuromethods ; 166 |
| DOI: | https://doi.org/10.1007/978-1-0716-1213-2_10 |
| Institutes: | Fakultät für Angewandte Informatik |
| Fakultät für Angewandte Informatik / Institut für Informatik | |
| Fakultät für Angewandte Informatik / Institut für Informatik / Professur für Informatik in der Medizintechnik | |
| Dewey Decimal Classification: | 0 Informatik, Informationswissenschaft, allgemeine Werke / 00 Informatik, Wissen, Systeme / 004 Datenverarbeitung; Informatik |
