Open Access

Muthuraman Muthuraman, Jan Raethjen, H. Hellriegel, Günther Deuschl, U. Heute

• The cortical sources of both the basic and first 'harmonic' frequency of Parkinsonian tremor are addressed in this paper. The power and coherence was estimated using the multitaper method for EEG and EMG data from 6 Parkinsonian patients with a classical rest tremor. The Dynamic Imaging of Coherent Sources (DICS) was used to find the coherent sources in the brain. Before hand this method was validated for the application to the EEG by showing in 3 normal subjects that rhythmic stimuli (1-5Hz) to the median nerve leads to almost identical coherent sources for the basic and first harmonic frequency in the contralateral sensorimotor cortex which is the biologically plausible result. In all the Parkinson patients the corticomuscular coherence was also present in the basic and the first harmonic frequency of the tremor. However, the source for the basic frequency was close to the frontal midline and the first harmonic frequency was in the region of premotor and sensory motor cortex on theThe cortical sources of both the basic and first 'harmonic' frequency of Parkinsonian tremor are addressed in this paper. The power and coherence was estimated using the multitaper method for EEG and EMG data from 6 Parkinsonian patients with a classical rest tremor. The Dynamic Imaging of Coherent Sources (DICS) was used to find the coherent sources in the brain. Before hand this method was validated for the application to the EEG by showing in 3 normal subjects that rhythmic stimuli (1-5Hz) to the median nerve leads to almost identical coherent sources for the basic and first harmonic frequency in the contralateral sensorimotor cortex which is the biologically plausible result. In all the Parkinson patients the corticomuscular coherence was also present in the basic and the first harmonic frequency of the tremor. However, the source for the basic frequency was close to the frontal midline and the first harmonic frequency was in the region of premotor and sensory motor cortex on the contralateral side for all the patients. Thus the generation of these two oscillations involves different cortical areas and possibly follows different pathways to the periphery.…