Rudolf Werner, Alexander Haug, Christian Buske, Simon Heidegger, Anna L. Illert, Florian Bassermann, Peter Herhaus, Andreas Buck, Johannes Duell, Max S. Topp, Sabrina Kraus, Hermann Einsele, Constantin Lapa, Markus Raderer, Georg Lenz, Stefan Habringer, Bastian von Tresckow, Ulrich Keller
- C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in a multitude of cancers, including neoplasms of hematopoietic origin. This feature can be leveraged by a theranostic approach, which provides a read-out of the actual CXCR4 expression in vivo, followed by CXCR4-targeted radioligand therapy (RLT) exerting anti-cancer as well as myeloablative efficacy. In a recent meeting of hematooncology and nuclear medicine specialists, statements on the current clinical practice and future perspectives of this innovative concept were proposed and summarized in this opinion article. Experts concluded that i) CXCR4-directed [68Ga]Ga-PentixaFor PET/CT has the potential to improve imaging for patients with marginal zone lymphoma; ii) CXCR4-targeted RLT exerts anti-lymphoma efficacy and myeloablative effects in patients with advanced, treatment-refractory T-cell lymphomas; iii) prospective trials with CXCR4-based imaging and theranostics are warranted.
MetadatenAuthor: | Rudolf Werner, Alexander Haug, Christian Buske, Simon Heidegger, Anna L. Illert, Florian Bassermann, Peter Herhaus, Andreas Buck, Johannes Duell, Max S. Topp, Sabrina Kraus, Hermann Einsele, Constantin LapaORCiDGND, Markus Raderer, Georg Lenz, Stefan Habringer, Bastian von Tresckow, Ulrich Keller |
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URN: | urn:nbn:de:bvb:384-opus4-1125846 |
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Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/112584 |
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ISSN: | 0029-5566OPAC |
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ISSN: | 2567-6407OPAC |
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Parent Title (Multiple languages): | Nuklearmedizin - NuclearMedicine |
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Publisher: | Georg Thieme |
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Place of publication: | Stuttgart |
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Type: | Article |
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Language: | English |
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Year of first Publication: | 2024 |
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Publishing Institution: | Universität Augsburg |
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Release Date: | 2024/04/22 |
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Tag: | Radiology, Nuclear Medicine and imaging; General Medicine |
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Volume: | 63 |
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Issue: | 2 |
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First Page: | 57 |
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Last Page: | 61 |
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DOI: | https://doi.org/10.1055/a-2194-9965 |
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Institutes: | Medizinische Fakultät |
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| Medizinische Fakultät / Universitätsklinikum |
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| Medizinische Fakultät / Lehrstuhl für Nuklearmedizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Licence (German): | CC-BY 4.0: Creative Commons: Namensnennung (mit Print on Demand) |
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