Causes of death and trends in mortality from the year 2000 to 2017 in patients with acute myocardial infarction

  • Objective To investigate the most common causes of death and trends in cause-specific long-term mortality in patients hospitalized for acute myocardial infarction (AMI). Methods This analysis was based on 10,718 patients, aged 25–74 years, recorded by the population-based Myocardial Infarction Registry Augsburg between 2000 and 2017. All hospitalized cases of AMI occurring in the study region during this period were included. If a patient died during follow-up (median: 6.6 years, IQR: 2.8–11.2) the death certificate was obtained and coded using the ICD-10 to determine the main cause of death. Cause-specific mortality was calculated for three 6-year periods. Multivariable adjusted Cox regression models stratified by time interval were calculated. Results The most common cause of death was cardiovascular disease (CVD), more precisely ischemic-heart disease (IHD), followed by cancer. The proportions of CVD deaths and IHD deaths were stable over time. An increasing trend wasObjective To investigate the most common causes of death and trends in cause-specific long-term mortality in patients hospitalized for acute myocardial infarction (AMI). Methods This analysis was based on 10,718 patients, aged 25–74 years, recorded by the population-based Myocardial Infarction Registry Augsburg between 2000 and 2017. All hospitalized cases of AMI occurring in the study region during this period were included. If a patient died during follow-up (median: 6.6 years, IQR: 2.8–11.2) the death certificate was obtained and coded using the ICD-10 to determine the main cause of death. Cause-specific mortality was calculated for three 6-year periods. Multivariable adjusted Cox regression models stratified by time interval were calculated. Results The most common cause of death was cardiovascular disease (CVD), more precisely ischemic-heart disease (IHD), followed by cancer. The proportions of CVD deaths and IHD deaths were stable over time. An increasing trend was observed in cancer mortality in post-AMI patients. In male patients, the hazard ratio for cancer mortality was 44.4% higher in 2012–2017 compared to 2000–2005, in female patients, it was more than twice as high in 2006–2012 compared to 2000–2005. Conclusion This study revealed consistent CVD and IHD long-term mortality and increasing trends in long-term cancer mortality in patients post-AMI. Thus, post-AMI patients should emphasize tertiary prevention of CVD by minimizing risk factors. Furthermore, patients should regularly undergo cancer screening programs. The reasons for the unfavorable development in terms of increasing cancer mortality should be investigated in further studies.show moreshow less

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Metadaten
Author:David Scharlach, Timo Schmitz, Philip RaakeGND, Jakob LinseisenGND, Christa MeisingerGND
URN:urn:nbn:de:bvb:384-opus4-1172860
Frontdoor URLhttps://opus.bibliothek.uni-augsburg.de/opus4/117286
ISSN:0785-3890OPAC
ISSN:1365-2060OPAC
Parent Title (English):Annals of Medicine
Publisher:Taylor & Francis
Type:Article
Language:English
Year of first Publication:2024
Publishing Institution:Universität Augsburg
Release Date:2024/12/04
Volume:56
Issue:1
First Page:2424449
DOI:https://doi.org/10.1080/07853890.2024.2424449
Institutes:Medizinische Fakultät
Medizinische Fakultät / Universitätsklinikum
Medizinische Fakultät / Lehrstuhl für Epidemiologie
Medizinische Fakultät / Lehrstuhl für Innere Medizin mit Schwerpunkt Kardiologie
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):CC-BY-NC 4.0: Creative Commons: Namensnennung - Nicht kommerziell (mit Print on Demand)