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A multicenter cohort study of early complications after cranioplasty: results of the German Cranial Reconstruction Registry (2022)
Sauvigny, Thomas ; Giese, Henrik ; Höhne, Julius ; Schebesch, Karl Michael ; Henker, Christian ; Strauss, Andreas ; Beseoglu, Kerim ; Spreckelsen, Niklas von ; Hampl, Jürgen A. ; Walter, Jan ; Ewald, Christian ; Krigers, Aleksandrs ; Petr, Ondra ; Butenschoen, Vicki M. ; Krieg, Sandro M. ; Wolfert, Christina ; Gaber, Khaled ; Mende, Klaus Christian ; Bruckner, Thomas ; Sakowitz, Oliver ; Lindner, Dirk ; Regelsberger, Jan ; Mielke, Dorothee
Effectiveness of lumbar cerebrospinal fluid drain among patients with aneurysmal subarachnoid hemorrhage (2023)
Wolf, Stefan ; Mielke, Dorothee ; Barner, Christoph ; Malinova, Vesna ; Kerz, Thomas ; Wostrack, Maria ; Czorlich, Patrick ; Salih, Farid ; Engel, Doortje C. ; Ehlert, Angelika ; Staykov, Dimitre ; Alturki, Abdulrahman Y. ; Sure, Ulrich ; Bardutzky, Jürgen ; Schroeder, Henry W. S. ; Schürer, Ludwig ; Beck, Jürgen ; Juratli, Tareq A. ; Fritsch, Michael ; Lemcke, Johannes ; Pohrt, Anne ; Meyer, Bernhard ; Schwab, Stefan ; Rohde, Veit ; Vajkoczy, Peter ; Baro, Norbert ; Bauer, Miriam ; Dengler, Nora F. ; von Dincklage, Falk ; Finger, Tobias ; Francis, Roland ; Hotter, Benjamin ; Hunsicker, Oliver ; Jussen, Daniel ; Jüttler, Eric ; Schaumann, Andreas ; Witsch, Jens ; Nagel, Christoph ; Meier, Ullrich ; Podlesik, Dino ; Schackert, Gabriele ; Huttner, Hagen ; Hagedorn, Sabine ; Müller, Daniela ; Müller, Oliver ; Sarge, Robert ; Niesen, Wolf-Dirk ; Lange, Katharina ; Päsler, Dennis ; Reinhardt, Stephanie ; Regelsberger, Jan ; Sauvigny, Thomas ; Westphal, Manfred ; Gremmer, Rudolf ; Beyer, Christian ; Beyer, Desiree ; Huthmann, Alexandra ; Landscheidt, Julia ; Schul, David B. ; Ryang, Yu-Mi ; Toeroek, Elisabeth ; Arouk, Wasim ; Al-Jehani, Hosam ; Sinclair, David B. ; Fung, Christian ; Soell, Nicole ; Hildebrandt, Gerhard ; Huscher, Karen ; Lange, Heidrun ; Hutchinson, Peter ; Tseng, Ming-Yuan
The importance of clinical registries in neurosurgery: is it time for a European registry? Response (2022)
Sauvigny, Thomas ; Giese, Henrik ; Regelsberger, Jan ; Mielke, Dorothee
Consensus-based recommendations for diagnosis and surgical management of cranioplasty and post-traumatic hydrocephalus from a European panel (2024)
Iaccarino, Corrado ; Chibbaro, Salvatore ; Sauvigny, Thomas ; Timofeev, Ivan ; Zaed, Ismail ; Franchetti, Silvio ; Mee, Harry ; Belli, Antonio ; Buki, Andras ; De Bonis, Pasquale ; Demetriades, Andreas K. ; Depreitere, Bart ; Fountas, Kostantinos ; Ganau, Mario ; Germanò, Antonino ; Hutchinson, Peter ; Kolias, Angelos ; Lindner, Dirk ; Lippa, Laura ; Marklund, Niklas ; McMahon, Catherine ; Mielke, Dorothee ; Nasi, Davide ; Peul, Wilco ; Poca, Maria Antonia ; Pompucci, Angelo ; Posti, Jussi P. ; Serban, Nicoleta-Larisa ; Splavski, Bruno ; Florian, Ioan Stefan ; Tasiou, Anastasia ; Zona, Gianluigi ; Servadei, Franco
Introduction Planning cranioplasty (CPL) in patients with suspected or proven post-traumatic hydrocephalus (PTH) poses a significant management challenge due to a lack of clear guidance. Research question This project aims to create a European document to improve adherence and adapt to local protocols based on available resources and national health systems. Methods After a thorough non-systematic review, a steering committee (SC) formed a European expert panel (EP) for a two-round questionnaire using the Delphi method. The questionnaire employed a 9-point Likert scale to assess the appropriateness of statements inherent to two sections: "Diagnostic criteria for PTH" and "Surgical strategies for PTH and cranial reconstruction." Results The panel reached a consensus on 29 statements. In the "Diagnostic criteria for PTH" section, five statements were deemed "appropriate" (consensus 74.2−90.3 %), two were labeled "inappropriate," and seven were marked as "uncertain." In the "Surgical strategies for PTH and cranial reconstruction" section, four statements were considered "appropriate" (consensus 74.2−90.4 %), six were "inappropriate," and five were "uncertain." Discussion and conclusion Planning a cranioplasty alongside hydrocephalus remains a significant challenge in neurosurgery. Our consensus conference suggests that, in patients with cranial decompression and suspected hydrocephalus, the most suitable diagnostic approach involves a combination of evolving clinical conditions and neuroradiological imaging. The recommended management sequence prioritizes cranial reconstruction, with the option of a ventriculoperitoneal shunt when needed, preferably with a programmable valve. We strongly recommend to adopt local protocols based on expert consensus, such as this, to guide patient care.
Fight INflammation to Improve outcome after aneurysmal Subarachnoid HEmorRhage (FINISHER) trial: study protocol for a randomized controlled trial (2022)
Güresir, Erdem ; Lampmann, Tim ; Bele, Sylvia ; Czabanka, Marcus ; Czorlich, Patrick ; Gempt, Jens ; Goldbrunner, Roland ; Hurth, Helene ; Hermann, Elvis ; Jabbarli, Ramazan ; Krauthausen, Marius ; König, Ralph ; Lindner, Dirk ; Malinova, Vesna ; Meixensberger, Jürgen ; Mielke, Dorothee ; Németh, Robert ; Darkwah Oppong, Marvin ; Pala, Andrej ; Prinz, Vincent ; Rashidi, Ali ; Roder, Constantin ; Sandalcioglu, Ibrahim Erol ; Sauvigny, Thomas ; Schebesch, Karl-Michael ; Timmer, Marco ; Vajkoczy, Peter ; Wessels, Lars ; Wild, Florian ; Wilhelm, Christoph ; Wostrack, Maria ; Vatter, Hartmut ; Coch, Christoph
German Cranial Reconstruction Registry (GCRR): protocol for a prospective, multicentre, open registry (2015)
Giese, Henrik ; Sauvigny, Thomas ; Sakowitz, Oliver W ; Bierschneider, Michael ; Güresir, Erdem ; Henker, Christian ; Höhne, Julius ; Lindner, Dirk ; Mielke, Dorothee ; Pannewitz, Robert ; Rohde, Veit ; Scholz, Martin ; Schuss, Patrick ; Regelsberger, Jan
German cranial reconstruction registry – a prospective multicenter cohort study: 883-day follow-up on the outcome and complications (2025)
Bschorer, Maximilian ; Giese, Henrik ; Höhne, Julius ; Schebesch, Karl Michael ; Henker, Christian ; Strauss, Andreas ; Wolfert, Christina ; Gaber, Khaled ; Krigers, Aleksandrs ; Petr, Ondra ; Butenschoen, Vicki M. ; Krieg, Sandro M. ; Mende, Klaus Christian ; Lindner, Dirk ; Regelsberger, Jan ; Mielke, Dorothee ; Sauvigny, Thomas
Introduction This international prospective multicenter cohort study investigates the long-term surgical complication rate and neurological outcomes in patients who underwent autologous or allogeneic cranioplasty (CP) after decompressive craniectomy (DC) for traumatic brain injury, stroke, aneurysmatic subarachnoid hemorrhage, and intracranial hemorrhage. Research question This study investigated the predictors of long-term outcomes and surgical revision after cranioplasty. Materials and methods Patients who underwent CP with a minimum follow-up of at least 12 months were included. Favorable long-term outcome (FLTO) was defined as a Glasgow Outcome Score (GOS) of 4 or 5 and a modified Rankin scale (mRS) score of <4. Univariate and multivariate analyses were performed. Results A total of 200 patients with a median follow-up of 883.1 520.5 days were included. Ninety-nine patients (50.0 %) had a FLTO, and the surgical revision rate was 25.0 % (n = 50). Thirty-eight percent (37.7 %) and 27.5 % of patients showed improvement in the mRS and GOS scores, respectively. Simultaneous implantation of a ventriculoperitoneal shunt (OR 6.114) and a time interval of <90 days between DC and CP (OR 2.189) predicted an increase in reoperation rates. The use of subcutaneous drains with suction predicted a lower rate of reoperation (OR .410). Diabetes mellitus (OR .221) and reoperations during the initial stay (OR .347) were negative predictors of FLTO. Implants imbued with antibiotics predicted a positive FLTO (OR 2.973). Discussion and conclusion Suction drains were predicted to reduce reoperation rates. Simultaneous implantation of VPS and CP within 3 months of DC predicted an increased likelihood of surgical revision.
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