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Introducing a FHIR-based toolset for analyzing nursing-related data (2025)
Netzband, Steffen ; Frei, Johann ; Weber, Florian ; Ignatenko, Yevgeniia ; Grieger, Milena ; Gottschalk, Florian ; Auer, Florian ; Müller, Dominik ; Brunner, Jens O. ; Kramer, Frank
Data analytics is a promising strategy to improve both the decision-making of nursing management and supporting nursing research, often constrained by the lack of standardized data sets. The HL7© Fast Healthcare Interoperability Resources (FHIR) standard offers a structured approach to addressing this issue, yet accessible software solutions for nursing-related FHIR data analysis are limited. This paper introduces an open-design framework to facilitate data-driven innovations in nursing research and practice, based on current developments in the German healthcare sector, such as the development of nursing-related FHIR specifications and the telematics infrastructure for secure data exchange. We present software implementations developed within this work for secure data exchange (Kommunikation im Medizinwesen Care) and the evaluation and visualization of nursing-related FHIR resources (FHIR QR Vis and FHIR Nursing Dashboard). The feasibility of this approach was validated through two case studies at a German nursing home and a university hospital, demonstrating its potential to enhance data-driven decision-making and workflow optimization in nursing.
A roadmap for integrating fairness in personnel planning and scheduling in hospitals (2025)
Fuchs, Gerriet ; Schimmelpfeng, Katja ; Brunner, Jens O.
The healthcare sector, and hospitals in particular, are confronted with an increasing challenge of staff shortages. To effectively address this issue, hospitals must enhance their workforce planning and scheduling processes in a manner that ensures fairness for employees. The application of operations research/management science methods offers significant promise for the integration of fairness into these processes. To assist researchers and practitioners in capitalizing on this potential, we present a comprehensive review of the extant literature. This review examines the current trends in the integration of fairness into workforce planning and scheduling in hospitals. It analyses 97 papers, providing insightful metadata and categorising the literature based on three key questions: what constitutes fairness, what metrics are crucial for assessing fairness, and how fairness can be quantitatively measured. By structuring our review around these questions, we identify gaps in existing research and suggest potential avenues for future research.
Project portfolio selection with strategic buckets — the role of naïve diversification (2025)
Fügener, Andreas ; Schiffels, Sebastian ; Thonemann, Ulrich W.
Problem definition: A company’s project portfolio is an important success factor. Employing strategic buckets to segment the overall budget into budgets for different project types is a commonly used approach for managing project selection. Strategic buckets typically refer to sets of projects of a certain type, such as safe and risky projects. A strategic bucket specification defines the number of buckets and thresholds between them. This paper addresses the question of how different strategic buckets specifications affect decision makers’ project selection behavior. Methodology/results: We develop a behavioral model of the effect of strategic buckets on project selection and use laboratory experiments to analyze how bucket specifications affect project selection decisions. For various strategic bucket specifications where a rational decision maker would allocate the budget to projects of the project type matching their risk preference only, we find that actual decision makers have the tendency to allocate the budget evenly among buckets and among project types within buckets. This observation can be explained by the naïve diversification bias, and we observe this effect in experimental settings with different selection processes, project definitions, and subject pools. Managerial implications: Our findings allow companies to better understand the effect of buckets guidelines on actual project selection behavior and to manage their project portfolio selection by choosing the right bucket specification.
Umwelt und Allergie: ein digitaler Umwelt-Gesundheits-Informationsdienst im Kurort Bad Hindelang [Abstract] (2025)
Holzmann, C. ; Karg, J. ; Reiger, M. ; Kharbal, R. ; Romano, P. ; Scheiwein, S. ; Khalfi, C. ; Muzalyova, Anna ; Brunner, Jens O. ; Hammel, Gertrud ; Damialis, Athanasios ; Traidl-Hoffmann, Claudia ; Plaza, Maria P. ; Gilles, Stefanie
Clinical benefits of a randomized allergy app intervention in grass pollen sufferers: a controlled trial (2025)
Holzmann, Caroline ; Karg, Johannes ; Reiger, Matthias ; Kharbal, Rajiv ; Romano, Paola ; Scheiwein, Sabrina ; Khalfi, Claudia ; Muzalyova, Anna ; Brunner, Jens O. ; Hammel, Gertrud ; Damialis, Athanasios ; Traidl‐Hoffmann, Claudia ; Plaza, María P. ; Gilles, Stefanie
Background Symptom monitoring can improve adherence to daily medication. However, controlled clinical trials on multi-modular allergy apps and their various functions have been difficult to implement. The objective of this study was to assess the clinical benefit of an allergy app with varying numbers of functions in reducing symptoms and improving quality of (QoL) life in grass pollen allergic individuals. The secondary objective was to develop a symptom forecast based on patient-derived and environmental data. Methods We performed a stratified, controlled intervention study (May–August 2023) with grass pollen allergic participants (N = 167) in Augsburg, Germany. Participants were divided into three groups, each receiving the same allergy app, but with increasing numbers of functions. Primary endpoint: rhinitis-related QoL; Secondary endpoints: symptom scores, relevant behavior, self-reported usefulness of the app, symptom forecast. Results Rhinitis-related QoL was increased after the intervention, with no statistical inter-group differences. However, participants with access to the full app version, including a pollen forecast, took more medication and reported lower symptoms and social activity impairment than participants with access to a reduced-function app. Using an XGBoost multiclass classification model, we achieved promising results for predicting nasal (accuracy: 0.79; F1-score: 0.78) and ocular (accuracy: 0.82; F1-score: 0.76) symptom levels and derived feature importance using SHAP as a guidance for future approaches. Conclusion Our allergy app with its high-performance pollen forecast, symptom diary, and general allergy-related information provides a clinical benefit for allergy sufferers. Reliable symptom forecasts may be created given high-quality and high-resolution data.
Task assignments with rotations and flexible shift starts to improve demand coverage and staff satisfaction in healthcare (2025)
Schoenfelder, Jan ; Heins, Jakob ; Brunner, Jens O.
In recent years, the importance of achieving staffing flexibility to balance supply and demand in unpredictable environments, such as hospitals, has grown. This study focuses on shift design with task rotations for a multi-skilled workforce, specifically in service contexts characterized by pronounced demand variability. We introduce a mathematical programming model designed to identify optimal shift start times with task assignments for both full-time and part-time employees, where workers can rotate between multiple tasks during their shifts. We develop a column generation approach that allows us to solve realistically-sized problem instances. Our analysis, derived from staffing data of a university hospital’s radiation oncology department, reveals the model's robust applicability across varying demand landscapes. We demonstrate that incorporating task rotations in the shift design can improve workload balancing when task demands fluctuate considerably. Remarkably, our column generation technique produces optimal integer solutions for realistic problem instances, outperforming the compact mixed-integer formulation which struggles to achieve feasible results. We find that the success of embedding task rotations in shift design decisions is directly influenced by the demand profile, which in turn affects the necessary qualification mix of the workforce.
Rehabilitation therapy scheduling accounting for teaming requirements and therapist shortages: a branch and price approach (2025)
Kling, Sebastian ; Schiffels, Sebastian ; Brunner, Jens O.
Physical therapy in acute care hospitals plays an important role for the rehabilitation of patients. Nevertheless, the profession must deal with staff shortages caused by a lack of qualified employees and stress-induced absenteeism. Both are results of high physical and mental workloads as well as a lack of employee retention strategies. A therapist shortage negatively affects the total number of appointments the department can fulfill daily. Furthermore, severe cases where patients require two therapists at the same time are common in acute care hospitals and contribute to the scheduling complexity. Here, one therapist takes charge of the appointment (lead), while a second therapist fulfills a support function role. This paper develops a multi-criteria optimization model for the daily rehabilitation therapy scheduling problem subject to teaming aspects and appointment priorities. We minimize preference penalties for lead and support visits and the total priority-based violation for unscheduled appointments. The problem is modeled as a vehicle routing problem with time windows and synchronization constraints. We solve the problem using a branch-and-price approach with different visit clustering methods and speed-up techniques. Computational results show the effectiveness of a randomized greedy heuristic implemented to enhance performance for generating new columns. Besides, a problem-specific clustering approach is integrated to speed up subproblems’ solution times. Our results show its high effectiveness when compared to a state-of-the-art approach derived from literature.
Generating insights on including flexibility in the planning processes of scarce resources in hospitals (2025)
Ebel, Stefanie
Hospitals are facing organizational and financial challenges in planning and scheduling. This dissertation presents three contributions which evaluate the surplus of considering flexibility in the resource planning processes. The research evaluates and discusses flexible room-changing opportunities in operating room scheduling, flexible shift types in staffing decisions, and flexible performance metrics in predicting patient diseases.
Automating airborne pollen classification: identifying and interpreting hard samples for classifiers (2025)
Milling, Manuel ; Rampp, Simon D. N. ; Triantafyllopoulos, Andreas ; Plaza, Maria P. ; Brunner, Jens O. ; Traidl-Hoffmann, Claudia ; Schuller, Björn W. ; Damialis, Athanasios
Deep-learning-based classification of pollen grains has been a major driver towards automatic monitoring of airborne pollen. Yet, despite an abundance of available datasets, little effort has been spent to investigate which aspects pose the biggest challenges to the (often black-box- resembling) pollen classification approaches. To shed some light on this issue, we conducted a sample-level difficulty analysis based on the likelihood for one of the largest automatically-generated datasets of pollen grains on microscopy images and investigated the reason for which certain airborne samples and specific pollen taxa pose particular problems to deep learning algorithms. It is here concluded that the main challenges lie in A) the (partly) co-occurring of multiple pollen grains in a single image, B) the occlusion of specific markers through the 2D capturing of microscopy images, and C) for some taxa, a general lack of salient, unique features. Our code is publicly available under https://github.com/millinma/SDPollen
Managing the patient portfolio using mathematical programming: decision support guidelines using a real-world use case at a university hospital (2024)
Grieger, Milena ; Heider, Steffen ; McRae, Sebastian ; Koperna, Thomas ; Brunner, Jens O.
Many hospitals in Germany are facing escalating economic pressures. After several years of stagnation, the number of inpatient hospital treatments dropped by in 2020 compared to the previous year. This negative tendency can also be seen in operating theaters (OTs). Strategic management of the case mix in hospital OTs now necessitates a solid data foundation. The case mix and the case mix index have become central economic indicators in contemporary hospital operations. In this work, we develop a mathematical model for case mix optimization at Augsburg University Hospital in Germany, which is based on an extensive data analysis with descriptive methods. The optimization model is subject to rigorous testing and evaluation through an extensive series of scenario analyses. The primary objective is to calculate a revenue-maximizing patient mix while respecting the available scarce personnel resources in the OT and intensive care unit. This research marks a pioneering effort in delineating the practical integration of case mix planning into a hospital’s routine operations using mathematical optimization. The analyses reveal a strong correlation between an upsurge in revenue and an increased number of cases. Furthermore, the results demonstrate that strategic planning of the patient mix has the potential to enhance revenue with existing resources. Even though the optimal patient mix may not be directly implementable in practice, the findings yield valuable insights for managerial decision-making. A critical examination of these results also fosters a nuanced discourse on the utilization of optimization models as decision support tools within hospital management.
Operational healthcare planning problems in an acute care setting with a focus on scarce resources (2024)
Kling, Sebastian
Evaluation of score-based tertiary triage policies during the COVID-19 pandemic: simulation study with real-world intensive care data (2025)
Bartenschlager, Christina C. ; Brunner, Jens O. ; Kubiciel, Michael ; Heller, Axel R.
Objective The explicit prohibition of discontinuing intensive care unit (ICU) treatment that has already begun by the newly established German Triage Act in favor of new patients with better prognoses (tertiary triage) under crisis conditions may prevent saving as many patients as possible and therefore may violate the international well-accepted premise of undertaking the “best for the most” patients. During the COVID-19 pandemic, authorities set up lockdown measures and infection-prevention strategies to avoid an overburdened health-care system. In cases of situational overload of ICU resources, when transporting options are exhausted, the question of a tertiary triage of patients arises. Methods We provide data-driven analyses of score- and non-score-based tertiary triage policies using simulation and real-world electronic health record data in a COVID-19 setting. Ten different triage policies, for example, based on the Simplified Acute Physiology Score (SAPS II), are compared based on the resulting mortality in the ICU and inferential statistics. Results Our study shows that score-based tertiary triage policies outperform non-score-based tertiary triage policies including compliance with the German Triage Act. Based on our simulation model, a SAPS II score-based tertiary triage policy reduces mortality in the ICU by up to 18 percentage points. The longer the queue of critical care patients waiting for ICU treatment and the larger the maximum number of patients subject to tertiary triage, the greater the effect on the reduction of mortality in the ICU. Conclusion A SAPS II score-based tertiary triage policy was superior in our simulation model. Random allocation or “first come, first served” policies yield the lowest survival rates, as will adherence to the new German Triage Act. An interdisciplinary discussion including an ethical and legal perspective is important for the social interpretation of our data-driven results.
Empowering advanced medical decision-making through machine learning in healthcare (2024)
Grieger, Milena
Machine learning offers significant potential to address challenges in healthcare. This dissertation explores three key contributions of machine learning and evaluates how these applications and methods can improve medical decision-making. Motivated by the pressing issues of escalating costs, nursing shortages, and bureaucratic burdens exacerbated by the Covid-19 pandemic, this study emphasizes the importance of machine learning in assisting clinical staff and enhancing decision-making accuracy in various medical scenarios. The research focuses primarily on supervised learning tasks, with an emphasis on binary classification. It categorizes the three contributions into one application and two methodological advancements within healthcare. The first application investigates the use of analytical and artificial intelligence-based methods in the triage of Covid-19 patients. The two methodological contributions explore the optimization of activation functions and loss functions to improve crucial performance metrics in healthcare, such as sensitivity and area under the curve. The dissertation addresses three critical research questions: the use of loss functions for flexible planning of intensive care unit capacity, the improvement of sensitivity-based binary classification through customized activation functions, and the integration of analytics and machine learning methods to enhance Covid-19 triage while ensuring algorithm explainability. The organization of the dissertation includes an introduction to the topic, an overview of the research contributions, an in-depth discussion of the results, and concluding remarks with directions for future research.
Optimizing physician schedules with resilient break assignments (2024)
Kraul, Sebastian ; Erhard, Melanie ; Brunner, Jens O.
This article presents a novel model for building biweekly rosters for physicians according to the regulations of a German teaching hospital, while also ensuring the viability of breaks. Currently, rosters are manually prepared by experienced physicians with basic spreadsheet knowledge, leading to significant costs and time consumption because of the complexity of the problem and the individual working conditions of the physicians. Unfortunately, manually generated rosters frequently prove to be non-compliant with labor regulations and ergonomic agreements, resulting in potential overtime hours and employee dissatisfaction. A particular concern is the inability of physicians to take mandatory breaks, which negatively affects both employee motivation and the hospital service level. To address these challenges, we propose a data-driven formulation of an operational physician scheduling problem, considering overstaffing and overtime hours as primary cost drivers and integrating shift preferences and break viability as ergonomic objectives. We develop and train a survival regression model to predict the viability of breaks, allowing practitioners to define break-time windows appropriately. Given the limitations of standard solvers in producing high-quality solutions within a reasonable timeframe, we adopt a Dantzig–Wolfe decomposition to reformulate the proposed model. Furthermore, we develop a branch-and-price algorithm to achieve optimal solutions and introduce a problem-specific variable selection strategy for efficient branching. To assess the algorithm’s effectiveness and examine the impact of the new break assignment constraint, we conducted a comprehensive computational study using real-world data from a German training hospital. Using our approach, healthcare institutions can streamline the rostering process, minimize the costs associated with overstaffing and overtime hours, and improve employee satisfaction by ensuring that physicians can take their legally mandated breaks. Ultimately, this contributes to better employee motivation and improves the overall level of hospital service.
Simulation of the mortality after different ex ante (secondary) and ex post (tertiary) triage methods in people with disabilities and pre-existing diseases (2023)
Garber, Sara ; Brunner, Jens O. ; Heller, Axel R. ; Marckmann, Georg ; Bartenschlager, Christina C.
The significant increase in patients during the COVID-19 pandemic presented the healthcare system with a variety of challenges. The intensive care unit is one of the areas particularly affected in this context. Only through extensive infection control measures as well as an enormous logistical effort was it possible to treat all patients requiring intensive care in Germany even during peak phases of the pandemic, and to prevent triage even in regions with high patient pressure and simultaneously low capacities. Regarding pandemic preparedness, the German Parliament passed a law on triage that explicitly prohibits ex post (tertiary) triage. In ex post triage, patients who are already being treated are included in the triage decision and treatment capacities are allocated according to the individual likelihood of success. Legal, ethical, and social considerations for triage in pandemics can be found in the literature, but there is no quantitative assessment with respect to different patient groups in the intensive care unit. This study addressed this gap and applied a simulation-based evaluation of ex ante (primary) and ex post triage policies in consideration of survival probabilities, impairments, and pre-existing conditions. The results show that application of ex post triage based on survival probabilities leads to a reduction in mortality in the intensive care unit for all patient groups. In the scenario close to a real-world situation, considering different impaired and prediseased patient groups, a reduction in mortality of approximately 15% was already achieved by applying ex post triage on the first day. This mortality-reducing effect of ex post triage is further enhanced as the number of patients requiring intensive care increases.
The AI ethics of digital COVID-19 diagnosis and their legal, medical, technological, and operational managerial implications (2024)
Bartenschlager, Christina C. ; Gassner, Ulrich M. ; Römmele, Christoph ; Brunner, Jens O. ; Schlögl-Flierl, Kerstin ; Ziethmann, Paula
The COVID-19 pandemic has given rise to a broad range of research from fields alongside and beyond the core concerns of infectiology, epidemiology, and immunology. One significant subset of this work centers on machine learning-based approaches to supporting medical decision-making around COVID-19 diagnosis. To date, various challenges, including IT issues, have meant that, notwithstanding this strand of research on digital diagnosis of COVID-19, the actual use of these methods in medical facilities remains incipient at best, despite their potential to relieve pressure on scarce medical resources, prevent instances of infection, and help manage the difficulties and unpredictabilities surrounding the emergence of new mutations. The reasons behind this research-application gap are manifold and may imply an interdisciplinary dimension. We argue that the discipline of AI ethics can provide a framework for interdisciplinary discussion and create a roadmap for the application of digital COVID-19 diagnosis, taking into account all disciplinary stakeholders involved. This article proposes such an ethical framework for the practical use of digital COVID-19 diagnosis, considering legal, medical, operational managerial, and technological aspects of the issue in accordance with our diverse research backgrounds and noting the potential of the approach we set out here to guide future research.
Scarce, scarcer, scarcest: sensitivity-flexible AI-based planning of elective surgeries for efficient and effective intensive care resource management [Abstract] (2024)
Grieger, Milena ; Brunner, Jens O. ; Heller, Axel R. ; Bartenschlager, Christina C.
Coordination of hospitals in the Corona pandemic (2021)
Neidel, Tobias ; Heins, Jakob ; Herrmann, Katharina ; Martignoni, André ; Zinsmeister, Thomas ; Dettmar, Roland ; Pukelsheim, Markus ; Brunner, Jens O. ; Heller, Axel R.
Endoscopic submucosal dissection for early esophageal adenocarcinoma: low rates of metastases in mucosal cancers with poor differentiation (2024)
Probst, Andreas ; Kappler, Felix ; Ebigbo, Alanna ; Albers, David ; Faiss, Siegbert ; Steinbrück, Ingo ; Wannhoff, Andreas ; Allgaier, Hans-Peter ; Denzer, Ulrike ; Rempel, Viktor ; Reinehr, Roland ; Dakkak, Dani ; Mende, Matthias ; Pohl, Jürgen ; Schaller, Tina ; Märkl, Bruno ; Muzalyova, Anna ; Fleischmann, Carola ; Messmann, Helmut
Background and aims Endoscopic resection (ER) is accepted as standard treatment for intramucosal esophageal adenocarcinoma (EAC) with well or moderate differentiation. Poor differentiation (PD) is judged as a risk factor for lymph node metastasis (LNM) and surgery is recommended. However, the evidence for this recommendation is weak. Study aim was to analyze the clinical course of patients after ER of EAC with PD. Patients and methods Patients undergoing endoscopic submucosal dissection for EAC were included from 16 German centers. Inclusion criteria were PD in the resection specimen, R0 resection and endoscopic follow-up. Primary outcome was the metastasis rate during follow-up. Analysis was performed retrospectively in a prospectively collected database. Results 25 patients with PD as single risk factor (group A) and 15 patients with PD and additional risk factors (submucosal invasion and/or lymphovascular invasion) were included. The metastasis rate was was 1/25 (4.0%; 95%CI 0.4-17.2) in group A and 3/15 (20.0%; 95%CI 6.0-44.4%) in group B, respectively (p=0.293). The rate of EAC-associated deaths was 1/25 (4%; 95%CI 0.4-17.2%) versus 3/15 (20%; 95%CI 6.0-44.4%) in group B (p=0.293) while the overall death rate was 7/25 (28.0%; 95%CI 13.5-47.3%) versus 3/15 (20%; 95%CI 6.0-44.4%) (p=0.715). Median follow-up was 30 months (IQR 15-53). Conclusions During long-term follow-up the risk of metastasis is low after ER of mucosal EAC with PD as single risk factor. A conservative approach seems justified in this small patient group. However, the treatment strategy has to be determined on an individualized basis until further prospective data are available.
Customized GRASP for rehabilitation therapy scheduling with appointment priorities and accounting for therapist satisfaction (2024)
Kling, Sebastian ; Kraul, Sebastian ; Brunner, Jens O.
Physical therapy in acute care hospitals plays an important role in the rehabilitation of patients. Nevertheless, the profession must deal with staff shortages caused by a lack of potential employees and absenteeism which are results of high physical and mental workloads. The therapist shortage negatively affects the total number of daily appointments the department can fulfill. For appointments that can be successfully scheduled, continuity of care with the same therapist cannot be guaranteed for individual patients. Lack of continuity of care negatively influences the therapist's satisfaction. Therapist preferences for individual appointments in general cannot always be guaranteed when designing schedules, which also hurts satisfaction. This paper develops a multi-criteria model for the daily therapy appointment-scheduling problem. The primary objective is to minimize the total sum of priority violations for unscheduled appointments. To improve therapist satisfaction, we consider therapist preferences including continuity of care as a secondary objective. Here, our integer programming formulation aims to minimize the total sum of preference violations for scheduled appointments. We are dealing with an operational planning problem with a daily planning horizon. The operational objective is to achieve therapist schedules in at most two hours. The therapists’ schedules together need to include several hundred appointments for a planning day. Due to intractability, the developed integer program cannot provide schedules for such problem sizes. Therefore, we develop a customized Greedy Randomized Adaptive Search Procedure (GRASP) with six innovative local search operations to improve an initially constructed solution. We test the heuristic algorithm on realistic data instances. The metaheuristic provides high-quality schedules for various problem sizes in short runtimes, i.e., within minutes. Comparisons with the optimal solutions for small problem instances show very good results of the GRASP with a similar number of scheduled appointments and good adherence to continuity of care and therapist preference requirements.
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