Epigenome-wide data collection in a case of gliofibroma
- Gliofibroma is a rare tumour entity with glial and mesenchymal histological features. We describe the case of a 30-year-old woman who presented with a short history of intermittent left-sided facial pain and paraesthesia of the left upper extremity. Histologically, the tumour consisted of a mixture of glial fibrillary acidic protein (GFAP)-positive glial cells and collagen-rich stroma. Immunohistochemical and molecular analysis showed no IDH1/2, BRAF, H3F3A mutations or ATP-dependent helicase (ATRX) loss in this tumour. Illumina Infinium HumanMethylation450 BeadChip array (HM450) methylation profile of the tumour was different from typical glioma entities. Genome-wide DNA copy number analysis showed partial loss of chromosome 3 and 8. All previous cases are reviewed. Our data support the classification of gliofibroma as a rare, but distinct brain tumour entity with good prognosis.
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| Author: | Felix BehlingORCiDGND, Florian Hennersdorf, Jens Schittenhelm |
|---|---|
| URN: | urn:nbn:de:bvb:384-opus4-1251508 |
| Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/125150 |
| ISSN: | 1641-4640OPAC |
| Parent Title (Polish): | Folia Neuropathologica |
| Publisher: | Termedia |
| Place of publication: | Poznań |
| Type: | Article |
| Language: | English |
| Year of first Publication: | 2021 |
| Publishing Institution: | Universität Augsburg |
| Release Date: | 2025/09/25 |
| Volume: | 59 |
| Issue: | 2 |
| First Page: | 212 |
| Last Page: | 218 |
| DOI: | https://doi.org/10.5114/fn.2021.106278 |
| Institutes: | Medizinische Fakultät |
| Medizinische Fakultät / Universitätsklinikum | |
| Medizinische Fakultät / Professur für translationale onkologische Neurochirurgie | |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Licence (German): |  CC-BY-NC-SA 4.0: Creative Commons: Namensnennung - Nicht kommerziell - Weitergabe unter gleichen Bedingungen (mit Print on Demand) |
