- Background: There is increasing evidence for the involvement of inflammatory processes in the genesis and growth of vestibular schwannomas. COX2 has been shown to be highly expressed in vestibular schwannomas and its role in tumor progression and as a potential therapy target are frequently discussed. However, the role of COX2 in vestibular schwannoma is still poorly understood.
Methods: We analyzed the expression of COX2 and markers for macrophage (CD163 and CD68) and lymphocyte infiltration (CD3 and CD8) in 1065 vestibular schwannoma tumor samples. Semiquantitative scoring systems were applied for the assessment of COX2, CD163 and CD68 expression while CD3 and CD8 immunopositivity was quantified via manual counting. Furthermore, clinical data was included in the uni- and multivariate analyses.
Results: An increased COX2 expression was associated with more extensive macrophage infiltration in vestibular schwannoma samples (CD68 and CD163 each p<0.0001). Additionally, lymphocyteBackground: There is increasing evidence for the involvement of inflammatory processes in the genesis and growth of vestibular schwannomas. COX2 has been shown to be highly expressed in vestibular schwannomas and its role in tumor progression and as a potential therapy target are frequently discussed. However, the role of COX2 in vestibular schwannoma is still poorly understood.
Methods: We analyzed the expression of COX2 and markers for macrophage (CD163 and CD68) and lymphocyte infiltration (CD3 and CD8) in 1065 vestibular schwannoma tumor samples. Semiquantitative scoring systems were applied for the assessment of COX2, CD163 and CD68 expression while CD3 and CD8 immunopositivity was quantified via manual counting. Furthermore, clinical data was included in the uni- and multivariate analyses.
Results: An increased COX2 expression was associated with more extensive macrophage infiltration in vestibular schwannoma samples (CD68 and CD163 each p<0.0001). Additionally, lymphocyte detection was also higher in tumors with higher COX2 immunopositivity (CD3 and CD8 each p<0.0001). Furthermore, with each higher score for COX2 expression the infiltration with lymphocytes and macrophages increased significantly (p<0.0001).
Conclusions: The extent of COX2 expression in vestibular schwannomas is clearly correlated with increased infiltration with lymphocytes and macrophages reflecting inflammatory processes.…
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