- Background: Preoperative hearing function shows wide variations among patients diagnosed with vestibular schwannoma. Although tumor size seems to be of importance other factors influencing hearing function are frequently discussed.
Methods: We analyzed clinical factors, imaging data and the expression of the proliferation marker MIB1 as potential influencing factors on the preoperative hearing function in a retrospective cohort of 268 vestibular schwannomas. Audiometry results were quantified applying the Gardner-Robertson Score. Uni- and multivariate analyses were performed.
Results: A Gardner-Robertson Score of 1 or 2 was documented in 191 patients (71.3%). Factors associated with a poor preoperative hearing function were patient age over 59.8 years (p<0.0001), prior radiotherapy (p=0.0105), a preoperative tumor volume over 6.34 cm3 (p=0.0395), widening of the internal acoustic meatus by at least 100% compared to the healthy side (p=0.0005) and an expression level of MIB1 of atBackground: Preoperative hearing function shows wide variations among patients diagnosed with vestibular schwannoma. Although tumor size seems to be of importance other factors influencing hearing function are frequently discussed.
Methods: We analyzed clinical factors, imaging data and the expression of the proliferation marker MIB1 as potential influencing factors on the preoperative hearing function in a retrospective cohort of 268 vestibular schwannomas. Audiometry results were quantified applying the Gardner-Robertson Score. Uni- and multivariate analyses were performed.
Results: A Gardner-Robertson Score of 1 or 2 was documented in 191 patients (71.3%). Factors associated with a poor preoperative hearing function were patient age over 59.8 years (p<0.0001), prior radiotherapy (p=0.0105), a preoperative tumor volume over 6.34 cm3 (p=0.0395), widening of the internal acoustic meatus by at least 100% compared to the healthy side (p=0.0005) and an expression level of MIB1 of at least 1.7% (p=0.0059). In the multivariate nominal logistic regression older age (OR 11.4, p=0.0001), higher MIB1 expression (OR 9.1, p=0.0034) and widening of the internal acoustic canal (OR 14.1, p=0.0079) were independent factors associated with poor preoperative hearing.
Conclusions: Poor preoperative hearing function in patients diagnosed with vestibular schwannoma are associated with advanced age, increased proliferative activity and widening of the internal acoustic canal.…
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