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Status and future development of heating and current drive for the EU DEMO (2022)
Tran, M. Q. ; Agostinetti, P. ; Aiello, G. ; Avramidis, K. ; Baiocchi, B. ; Barbisan, M. ; Bobkov, V. ; Briefi, Stefan ; Bruschi, A. ; Chavan, R. ; Chelis, I. ; Day, Ch. ; Delogu, R. ; Ell, B. ; Fanale, F. ; Fassina, A. ; Fantz, Ursel ; Faugel, H. ; Figini, L. ; Fiorucci, D. ; Friedl, Roland ; Franke, Th. ; Gantenbein, G. ; Garavaglia, S. ; Granucci, G. ; Hanke, S. ; Hogge, J.-P. ; Hopf, C. ; Kostic, A. ; Illy, S. ; Ioannidis, Z. ; Jelonnek, J. ; Jin, J. ; Latsas, G. ; Louche, F. ; Maquet, V. ; Maggiora, R. ; Messiaen, A. ; Milanesio, D. ; Mimo, A. ; Moro, A. ; Ochoukov, R. ; Ongena, J. ; Pagonakis, I. G. ; Peponis, D. ; Pimazzoni, A. ; Ragona, R. ; Rispoli, N. ; Ruess, T. ; Rzesnicki, T. ; Scherer, T. ; Spaeh, P. ; Starnella, G. ; Strauss, D. ; Thumm, M. ; Tierens, W. ; Tigelis, I. ; Tsironis, C. ; Usoltceva, M. ; Van Eester, D. ; Veronese, F. ; Vincenzi, P. ; Wagner, F. ; Wu, C. ; Zeus, F. ; Zhang, W.
The European DEMO is a pulsed device with pulse length of 2 hours. The functions devoted to the heating and current drive system are: plasma breakdown, plasma ramp-up to the flat-top where fusion reactions occur, the control of the plasma during the flat-top phase, and finally the plasma ramp-down. The EU-DEMO project was in a Pre-Concept Design Phase during 2014-2020, meaning that in some cases, the design values of the device and the precise requirements from the physics point of view were not yet frozen. A total of 130 MW was considered for the all phases of the plasma: in the flat top, 30 MW is required for neoclassical tearing modes (NTM) control, 30 MW for burn control, and 70 MW for the control of thermal instability (TI), without any specific functions requested from each system, Electron Cyclotron (EC), Ion Cyclotron (IC), or Neutral Beam (NB) Injection. At the beginning of 2020, a strategic decision was taken, to consider EC as the baseline for the next phase (in 2021 and beyond). R&D on IC and NB will be risk mitigation measures. In parallel with progresses in Physics modelling, a decision point on the heating strategy will be taken by 2024. This paper describes the status of the R&D development during the period 2014-2020. It assumes that the 3 systems EC, IC and NB will be needed. For integration studies, they are assumed to be implemented at a power level of at least 50 MW. This paper describes in detail the status reached by the EC, IC and NB at the end of 2020. It will be used in the future for further development of the baseline heating method EC, and serves as starting point to further develop IC and NB in areas needed for these systems to be considered for DEMO.
Systematic evaluation of pleiotropy identifies 6 further loci associated with coronary artery disease (2017)
Webb, Thomas R. ; Erdmann, Jeanette ; Stirrups, Kathleen E. ; Stitziel, Nathan O. ; Masca, Nicholas G. ; Jansen, Henning ; Kanoni, Stavroula ; Nelson, Christopher P. ; Ferrario, Paola G. ; König, Inke R. ; Eicher, John D. ; Johnson, Andrew D. ; Hamby, Stephen E. ; Betsholtz, Christer ; Ruusalepp, Arno ; Franzén, Oscar ; Schadt, Eric E. ; Björkegren, Johan L. ; Weeke, Peter E. ; Auer, Paul L. ; Schick, Ursula M. ; Lu, Yingchang ; Zhang, He ; Dube, Marie-Pierre ; Goel, Anuj ; Farrall, Martin ; Peloso, Gina M. ; Won, Hong-Hee ; Do, Ron ; van Iperen, Erik ; Kruppa, Jochen ; Mahajan, Anubha ; Scott, Robert A. ; Willenborg, Christina ; Braund, Peter S. ; van Capelleveen, Julian C. ; Doney, Alex S. ; Donnelly, Louise A. ; Asselta, Rosanna ; Merlini, Pier A. ; Duga, Stefano ; Marziliano, Nicola ; Denny, Josh C. ; Shaffer, Christian ; El-Mokhtari, Nour Eddine ; Franke, Andre ; Heilmann, Stefanie ; Hengstenberg, Christian ; Hoffmann, Per ; Holmen, Oddgeir L. ; Hveem, Kristian ; Jansson, Jan-Håkan ; Jöckel, Karl-Heinz ; Kessler, Thorsten ; Kriebel, Jennifer ; Laugwitz, Karl L. ; Marouli, Eirini ; Martinelli, Nicola ; McCarthy, Mark I. ; Van Zuydam, Natalie R. ; Meisinger, Christa ; Esko, Tõnu ; Mihailov, Evelin ; Escher, Stefan A. ; Alver, Maris ; Moebus, Susanne ; Morris, Andrew D. ; Virtamo, Jarma ; Nikpay, Majid ; Olivieri, Oliviero
Genome-wide association study of kidney function decline in individuals of European descent (2015)
Gorski, Mathias ; Tin, Adrienne ; Garnaas, Maija ; McMahon, Gearoid M. ; Chu, Audrey Y. ; Tayo, Bamidele O. ; Pattaro, Cristian ; Teumer, Alexander ; Chasman, Daniel I. ; Chalmers, John ; Hamet, Pavel ; Tremblay, Johanne ; Woodward, Marc ; Aspelund, Thor ; Eiriksdottir, Gudny ; Gudnason, Vilmundur ; Harris, Tamara B. ; Launer, Lenore J. ; Smith, Albert V. ; Mitchell, Braxton D. ; O'Connell, Jeffrey R. ; Shuldiner, Alan R. ; Coresh, Josef ; Li, Man ; Freudenberger, Paul ; Hofer, Edith ; Schmidt, Helena ; Schmidt, Reinhold ; Holliday, Elizabeth G. ; Mitchell, Paul ; Wang, Jie Jin ; de Boer, Ian H. ; Li, Guo ; Siscovick, David S. ; Kutalik, Zoltan ; Corre, Tanguy ; Vollenweider, Peter ; Waeber, Gérard ; Gupta, Jayanta ; Kanetsky, Peter A. ; Hwang, Shih-Jen ; Olden, Matthias ; Yang, Qiong ; de Andrade, Mariza ; Atkinson, Elizabeth J. ; Kardia, Sharon L.R. ; Turner, Stephen T. ; Stafford, Jeanette M. ; Ding, Jingzhong ; Liu, Yongmei ; Barlassina, Cristina ; Cusi, Daniele ; Salvi, Erika ; Staessen, Jan A. ; Ridker, Paul M. ; Grallert, Harald ; Meisinger, Christa ; Müller-Nurasyid, Martina ; Krämer, Bernhard K. ; Kramer, Holly ; Rosas, Sylvia E. ; Nolte, Ilja M. ; Penninx, Brenda W. ; Snieder, Harold ; Fabiola Del Greco, M. ; Franke, Andre ; Nöthlings, Ute ; Lieb, Wolfgang ; Bakker, Stephan J.L. ; Gansevoort, Ron T. ; van der Harst, Pim ; Dehghan, Abbas ; Franco, Oscar H. ; Hofman, Albert ; Rivadeneira, Fernando ; Sedaghat, Sanaz ; Uitterlinden, André G. ; Coassin, Stefan ; Haun, Margot ; Kollerits, Barbara ; Kronenberg, Florian ; Paulweber, Bernhard ; Aumann, Nicole ; Endlich, Karlhans ; Pietzner, Mike ; Völker, Uwe ; Rettig, Rainer ; Chouraki, Vincent ; Helmer, Catherine ; Lambert, Jean-Charles ; Metzger, Marie ; Stengel, Benedicte ; Lehtimäki, Terho ; Lyytikäinen, Leo-Pekka ; Raitakari, Olli ; Johnson, Andrew ; Parsa, Afshin ; Bochud, Murielle ; Heid, Iris M. ; Goessling, Wolfram ; Köttgen, Anna ; Linda Kao, W.H. ; Fox, Caroline S. ; Böger, Carsten A.
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations (2012)
Demirkan, Ayşe ; van Duijn, Cornelia M. ; Ugocsai, Peter ; Isaacs, Aaron ; Pramstaller, Peter P. ; Liebisch, Gerhard ; Wilson, James F. ; Johansson, Åsa ; Rudan, Igor ; Aulchenko, Yurii S. ; Kirichenko, Anatoly V. ; Janssens, A. Cecile J. W. ; Jansen, Ritsert C. ; Gnewuch, Carsten ; Domingues, Francisco S. ; Pattaro, Cristian ; Wild, Sarah H. ; Jonasson, Inger ; Polasek, Ozren ; Zorkoltseva, Irina V. ; Hofman, Albert ; Karssen, Lennart C. ; Struchalin, Maksim ; Floyd, James ; Igl, Wilmar ; Biloglav, Zrinka ; Broer, Linda ; Pfeufer, Arne ; Pichler, Irene ; Campbell, Susan ; Zaboli, Ghazal ; Kolcic, Ivana ; Rivadeneira, Fernando ; Huffman, Jennifer ; Hastie, Nicholas D. ; Uitterlinden, Andre ; Franke, Lude ; Franklin, Christopher S. ; Vitart, Veronique ; Nelson, Christopher P. ; Preuss, Michael ; Bis, Joshua C. ; O'Donnell, Christopher J. ; Franceschini, Nora ; Witteman, Jacqueline C. M. ; Axenovich, Tatiana ; Oostra, Ben A. ; Meitinger, Thomas ; Hicks, Andrew A. ; Hayward, Caroline ; Wright, Alan F. ; Gyllensten, Ulf ; Campbell, Harry ; Schmitz, Gerd
Circulation dynamics and its influence on European and Mediterranean January–April climate over the past half millennium: results and insights from instrumental data, documentary evidence and coupled climate models (2010)
Luterbacher, J. ; Koenig, S. J. ; Franke, J. ; van der Schrier, G. ; Zorita, E. ; Moberg, A. ; Jacobeit, Jucundus ; Della-Marta, P. M. ; Küttel, M. ; Xoplaki, E. ; Wheeler, D. ; Rutishauser, T. ; Stössel, M. ; Wanner, H. ; Brázdil, R. ; Dobrovolný, P. ; Camuffo, D. ; Bertolin, C. ; van Engelen, A. ; Gonzalez-Rouco, F. J. ; Wilson, R. ; Pfister, C. ; Limanówka, D. ; Nordli, Ø. ; Leijonhufvud, L. ; Söderberg, J. ; Allan, R. ; Barriendos, M. ; Glaser, Rüdiger ; Riemann, D. ; Hao, Z. ; Zerefos, C. S.
Discovery and fine mapping of serum protein loci through transethnic meta-analysis (2012)
Franceschini, Nora ; van Rooij, Frank J.A. ; Prins, Bram P. ; Feitosa, Mary F. ; Karakas, Mahir ; Eckfeldt, John H. ; Folsom, Aaron R. ; Kopp, Jeffrey ; Vaez, Ahmad ; Andrews, Jeanette S. ; Baumert, Jens ; Boraska, Vesna ; Broer, Linda ; Hayward, Caroline ; Ngwa, Julius S. ; Okada, Yukinori ; Polasek, Ozren ; Westra, Harm-Jan ; Wang, Ying A. ; Del Greco M., Fabiola ; Glazer, Nicole L. ; Kapur, Karen ; Kema, Ido P. ; Lopez, Lorna M. ; Schillert, Arne ; Smith, Albert V. ; Winkler, Cheryl A. ; Zgaga, Lina ; Bandinelli, Stefania ; Bergmann, Sven ; Boban, Mladen ; Bochud, Murielle ; Chen, Y.D. ; Davies, Gail ; Dehghan, Abbas ; Ding, Jingzhong ; Doering, Angela ; Durda, J. Peter ; Ferrucci, Luigi ; Franco, Oscar H. ; Franke, Lude ; Gunjaca, Grog ; Hofman, Albert ; Hsu, Fang-Chi ; Kolcic, Ivana ; Kraja, Aldi ; Kubo, Michiaki ; Lackner, Karl J. ; Launer, Lenore ; Loehr, Laura R. ; Li, Guo ; Meisinger, Christa ; Nakamura, Yusuke ; Schwienbacher, Christine ; Starr, John M. ; Takahashi, Atsushi ; Torlak, Vesela ; Uitterlinden, André G. ; Vitart, Veronique ; Waldenberger, Melanie ; Wild, Philipp S. ; Kirin, Mirna ; Zeller, Tanja ; Zemunik, Tatijana ; Zhang, Qunyuan ; Ziegler, Andreas ; Blankenberg, Stefan ; Boerwinkle, Eric ; Borecki, Ingrid B. ; Campbell, Harry ; Deary, Ian J. ; Frayling, Timothy M. ; Gieger, Christian ; Harris, Tamara B. ; Hicks, Andrew A. ; Koenig, Wolfgang ; O’Donnell, Christopher J. ; Fox, Caroline S. ; Pramstaller, Peter P. ; Psaty, Bruce M. ; Reiner, Alex P. ; Rotter, Jerome I. ; Rudan, Igor ; Snieder, Harold ; Tanaka, Toshihiro ; van Duijn, Cornelia M. ; Vollenweider, Peter ; Waeber, Gerard ; Wilson, James F. ; Witteman, Jacqueline C.M. ; Wolffenbuttel, Bruce H.R. ; Wright, Alan F. ; Wu, Qingyu ; Liu, Yongmei ; Jenny, Nancy S. ; North, Kari E. ; Felix, Janine F. ; Alizadeh, Behrooz Z. ; Cupples, L. Adrienne ; Perry, John R.B. ; Morris, Andrew P.
Host traits, lifestyle and environment are associated with the human skin bacteria (2021)
Moitinho‐Silva, L. ; Boraczynski, N. ; Emmert, H. ; Baurecht, H. ; Szymczak, S. ; Schulz, H. ; Haller, D. ; Linseisen, Jakob ; Gieger, C. ; Peters, A. ; Tittmann, L. ; Lieb, W. ; Bang, C. ; Franke, A. ; Rodriguez, E. ; Weidinger, S.
Long-term survival in patients suffering from AML with a complex aberrant karyotype after early allogeneic stem cell transplantation using the FLAMSA-RIC regimen: results from a prospective phase II trial (2008)
Schmid, Christoph ; Schleuning, M. ; Tischer, J. ; Hahn, J. ; Baurmann, H. ; Schwerdtfeger, R. ; Ledderose, G. ; Lallinger, C. ; Franke, A. ; Cook, A. ; Holler, E. ; Hiddemann, W. ; Kolb, H. J.
S2k-Leitlinie - Kurzversion: katastrophenmedizinische prähospitale Behandlungsleitlinien (2024)
Rohde, A. ; Francis, R. ; Gräsner, J.-T. ; Heller, Axel R. ; Latasch, L. ; Franke, A.
Comparative Study of the Dynamics of Lipid Membrane Phase Decomposition in Experiment and Simulation (2012)
Burger, Stefan ; Fraunholz, Thomas ; Leirer, Christian T. ; Hoppe, Ronald H. W. ; Wixforth, Achim ; Peter, Malte A. ; Franke, Thomas
Phase decomposition in lipid membranes has been the subject of numerous investigations both experimentally and by theoretical simulation. Yet quantitative comparisons of the simulated data to the experimental results are rare. In this work we present a novel way of comparing the temporal development of liquid ordered domains obtained from numerically solving the Cahn–Hilliard equation and by inducing phase transition in giant unilamellar vesicles (GUVs). Quantitative comparison is done by calculating the structure factor of the domain pattern. It turns out that the decomposition takes place in three distinct regimes both in experiment and simulation. These regimes are characterized by different rates of growth of the mean domain diameter and there is a quantitative agreement between experiment and simulation as to the duration of each regime and the absolute rate of growth in each regime.
Comparative study of the dynamics of lipid membrane phase decomposition in experiment and simulation (2013)
Burger, Stefan ; Fraunholz, Thomas ; Leirer, Christian T. ; Hoppe, Ronald H. W. ; Wixforth, Achim ; Peter, Malte A. ; Franke, Thomas
Transport at interfaces in lipid membranes and enantiomer separation (2017)
Boyarkin, Oleg ; Burger, Stefan ; Franke, Thomas ; Fraunholz, Thomas ; Hoppe, Ronald H. W. ; Kirschler, Simon ; Lindner, Kevin ; Peter, Malte A. ; Strobl, Florian G. ; Wixforth, Achim
Numerical simulation of surface acoustic wave actuated separation of rigid enantiomers by the fictitious domain Lagrange multiplier method (2015)
Burger, Stefan ; Franke, Thomas ; Fraunholz, Thomas ; Hoppe, Ronald H. W. ; Peter, Malte A. ; Wixforth, Achim
High-Voltage Dielectrophoretic and Magnetophoretic Hybrid Integrated Circuit/Microfluidic Chip (2009)
Issadore, David ; Franke, Thomas ; Brown, Keith A. ; Hunt, Thomas P. ; Westervelt, Robert M.
Cell and droplet sorting with surface acoustic waves in microfluidics [Abstract] (2010)
Franke, Thomas ; Wixforth, Achim ; Weitz, David A.
Conceptual design of the beam source for the DEMO Neutral Beam Injectors (2016)
Sonato, P. ; Agostinetti, P. ; Fantz, Ursel ; Franke, T. ; Furno, I. ; Simonin, A. ; Tran, M. Q.
Novel surface acoustic wave (SAW)-driven closed PDMS flow chamber (2012)
Schmid, Lothar ; Wixforth, Achim ; Weitz, David A. ; Franke, Thomas
Conceptual design of the DEMO neutral beam injectors: main developments and R&D achievements (2017)
Sonato, P. ; Agostinetti, P. ; Bolzonella, T. ; Cismondi, F. ; Fantz, Ursel ; Fassina, A. ; Franke, T. ; Furno, I. ; Hopf, C. ; Jenkins, I. ; Sartori, E. ; Tran, M. Q. ; Varje, J. ; Vincenzi, P. ; Zanotto, L.
Magneto-mechanical mixing and manipulation of picoliter volumes in vesicles (2009)
Franke, Thomas ; Schmid, Lothar ; Weitz, David A. ; Wixforth, Achim
Surface acoustic wave (SAW) directed droplet flow in microfluidics for PDMS devices (2009)
Franke, Thomas ; Abate, Adam R. ; Weitz, David A. ; Wixforth, Achim
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