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Recent experiments at ASDEX Upgrade have achieved advanced scenarios with high βN (>3) and confinement enhancement over ITER98(y, 2) scaling, HH98y2 = 1.1–1.5, in steady state. These discharges have been obtained in a modified divertor configuration for ASDEX Upgrade, allowing operation at higher triangularity, and with a changed neutral beam injection (NBI) system, for a more tangential, off-axis beam deposition. The figure of merit, βNHITER89-P, reaches up to 7.5 for several seconds in plasmas approaching stationary conditions. These advanced tokamak discharges have low magnetic shear in the centre, with q on-axis near 1, and edge safety factor, q95 in the range 3.3–4.5. This q-profile is sustained by the bootstrap current, NBI-driven current and fishbone activity in the core. The off-axis heating leads to a strong peaking of the density profile and impurity accumulation in the core. This can be avoided by adding some central heating from ion cyclotron resonance heating or electron cyclotron resonance heating, since the temperature profiles are stiff in this advanced scenario (no internal transport barrier). Using a combination of NBI and gas fuelling line, average densities up to 80–90% of the Greenwald density are achieved, maintaining good confinement. The best integrated results in terms of confinement, stability and ability to operate at high density are obtained in highly shaped configurations, near double null, with δ = 0.43. At the highest densities, a strong reduction of the edge localized mode activity similar to type II activity is observed, providing a steady power load on the divertor, in the range of 6 MW m−2, despite the high input power used (>10 MW).
Mobile measurement techniques for local and micro-scale studies in urban and topo-climatology
(2016)
Technical development during the last two decades has brought new potential and new applications for mobile measurements. In this paper, we present six case studies where mobile measurement devices were used to acquire data for meteorological and climatological research. Three case studies deal with ground-based mobile measurements – on buses for urban climate measurements and on a vessel on a lake – and three with airborne platforms – on a cable car and on an unmanned aerial vehicle for vertical soundings and on a tethered balloon sonde for cloud physics. For each study, we describe the measurement set-up and address the potential and drawbacks of these applications. At the end, we discuss general aspects related to mobile observations especially concerning the time and space dimension of measurements.
The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75–78 clinically relevant drugs. We included 132 viable tumor samples from 35 pediatric oncology centers in seven countries. DSP was conducted on multicellular fresh tumor tissue spheroid cultures in 384-well plates with an overall mean processing time of three weeks. In 89 cases (67%), sufficient viable tissue was received; 69 (78%) passed internal quality controls. The DSP results matched the identified molecular targets, including BRAF, ALK, MET, and TP53 status. Drug vulnerabilities were identified in 80% of cases lacking actionable (very) high-evidence molecular events, adding value to the molecular data. Striking parallels between clinical courses and the DSP results were observed in selected patients. Overall, DSP in clinical real-time is feasible in international multicenter precision oncology programs.
