Numerical Simulation of Surface Acoustic Wave Actuated Enantiomer Separation by the Finite Element Immersed Boundary Method

  • Enantiomers are chiral objects such as chemical molecules that can be distinguished by their handedness. They typically occur as racemic compounds of left- and right-handed species which may have completely different properties. Therefore, in applications such as drug design in pharmacology, enantiomer separation is an important issue. Here, we present a new technology for enantiomer separation by surface acoustic wave generated vorticity patterns consisting of pairwise counter-rotating vortices in a carrier fluid. The enantiomers are injected onto the surface of the fluid between two counter-rotating vortices such that right-handed (left-handed) enantiomers get attracted by left-rotating (right-rotating) vortices. In particular, we are concerned with the numerical simulation of this separation process by an application of the finite element immersed boundary method which relies on the solution of a coupled system consisting of the incompressible Navier-Stokes equations and theEnantiomers are chiral objects such as chemical molecules that can be distinguished by their handedness. They typically occur as racemic compounds of left- and right-handed species which may have completely different properties. Therefore, in applications such as drug design in pharmacology, enantiomer separation is an important issue. Here, we present a new technology for enantiomer separation by surface acoustic wave generated vorticity patterns consisting of pairwise counter-rotating vortices in a carrier fluid. The enantiomers are injected onto the surface of the fluid between two counter-rotating vortices such that right-handed (left-handed) enantiomers get attracted by left-rotating (right-rotating) vortices. In particular, we are concerned with the numerical simulation of this separation process by an application of the finite element immersed boundary method which relies on the solution of a coupled system consisting of the incompressible Navier-Stokes equations and the equations of motion of the immersed enantiomers described with respect to an Eulerian and a Lagrangian coordinate system. For a model system of deformable, initially L-shaped enantiomers the results of the numerical simulations reveal a perfect separation.show moreshow less

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Metadaten
Author:Ronald H. W. HoppeGND, Christopher LinsenmannGND, Kidist Zeleke
URN:urn:nbn:de:bvb:384-opus4-20642
Frontdoor URLhttps://opus.bibliothek.uni-augsburg.de/opus4/2064
Series (Serial Number):Preprints des Instituts für Mathematik der Universität Augsburg (2012-10)
Type:Preprint
Language:English
Publishing Institution:Universität Augsburg
Contributing Corporation:University of Houston
Release Date:2012/10/09
Tag:fluid mechanics; surface acoustic waves; finite element immersed boundary method
enantiomer separation
GND-Keyword:Strömungsmechanik; Akustische Oberflächenwelle; Finite-Elemente-Methode
Institutes:Mathematisch-Naturwissenschaftlich-Technische Fakultät
Mathematisch-Naturwissenschaftlich-Technische Fakultät / Institut für Mathematik
Mathematisch-Naturwissenschaftlich-Technische Fakultät / Institut für Mathematik / Lehrstuhl für Numerische Mathematik
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 51 Mathematik / 510 Mathematik
Licence (German):License LogoDeutsches Urheberrecht mit Print on Demand